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P-type calcium channels play a key role in the synaptic transmission between mammalian central neurons since a major part of calcium entering pre-synaptic terminals is delivered via these channels. Using conventional whole-cell patch clamp techniques we have studied the effect of μ-opioids on P-type calcium channels in acutely isolated Purkinje neurons from rat cerebellum. The selective μ-opioid agonist...
A novel polypeptide, designated ω-Lsp-IA, which modulates P-type Ca 2+ channels, was purified from the venom of the spider Geolycosa sp. ω-Lsp-IA contains 47 amino acid residues and 4 intramolecular disulfide bridges. It belongs to a group of spider toxins affecting Ca 2+ channels and presumably forms the inhibitor cystine knot (ICK) fold. Peculiar structural features (a cluster of...
We have identified a novel polypeptide toxin (Lsp-1) from the venom of the spider Lycosa (LS). Its effect has been examined on the P-type calcium channels in Purkinje neurons, using whole-cell patch-clamp. This toxin (at saturating concentration 7nM) produces prominent (four-fold) deceleration of the activation kinetics and partial (71±6%) decrease of the amplitude of P-current without affecting either...
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