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Approximately 25% of the λ6 light chains have glycine rather than arginine at position 25, which is an allelic variant of the IGLV6‐57 (6a) locus. The Gly25 variant has been shown to decrease the folding stability of the germline λ6 VL protein 6aJL2 by 1.7 kcal·mol−1. In this work, we compared the thermodynamic and fibrillogenic properties of the amyloidosis (AL) derived recombinant (r) VL protein...