The FEBS Journal

An increasing amount of expressed sequence tag (EST) and genomic data, predominantly for the cnidarians Acropora, Hydra and Nematostella, reveals that cnidarians have a high genomic complexity, despite being one of the morphologically simplest multicellular animals. Considering the diversity of cnidarians, we performed an EST project on the hydroid Hydractinia echinata, to contribute towards a broader...

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Binase cleaves cellular noncoding RNAs and affects coding mRNAs

Vladimir A. Mitkevich, Nickolai A. Tchurikov, Pavel V. Zelenikhin, Irina Yu. Petrushanko, more

The FEBS Journal > 277 > 1 > 186 - 196

Bacterial RNases are promising tools for the development of anticancer drugs. Neoplastic transformation leads to enhanced accumulation of rRNA and tRNA, and altered expression of regulatory noncoding RNAs. Cleavage of RNA in cancer cells is the main reason for the cytotoxic effects of exogenic RNases. We have shown that binase, a cytotoxic ribonuclease from Bacillus intermedius, affects the total...

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Death‐associated protein kinase (DAPK) and signal transduction

Ted R. Hupp

The FEBS Journal > 277 > 1 > 47 - 47

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Death‐associated protein kinase (DAPK) and signal transduction: blebbing in programmed cell death

Miia Bovellan, Marco Fritzsche, Craig Stevens, Guillaume Charras

The FEBS Journal > 277 > 1 > 58 - 65

Death‐associated protein kinase (DAPK) regulates many distinct signalling events, including apoptosis, autophagy and membrane blebbing. The role of DAPK in the blebbing process is only beginning to be understood and, in this review, we will first summarize what is known about the cytoskeletal proteins and signalling cascades that participate in bleb growth and retraction and then highlight how DAPK...

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ERK and cell death: ERK1/2 in neuronal death

Srinivasa Subramaniam, Klaus Unsicker

The FEBS Journal > 277 > 1 > 22 - 29

Extracellular signal‐regulated kinase (ERK) is a versatile protein kinase that regulates many cellular functions. Growing evidence suggests that ERK1/2 plays a crucial role in promoting cell death in a variety of neuronal systems, including neurodegenerative diseases. It is believed that the magnitude and the duration of ERK1/2 activity determine its cellular function. In this review, we summarize...

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Author index

The FEBS Journal > 277 > 1 > 276 - 276

article

ERK and cell death: Mechanisms of ERK‐induced cell death – apoptosis, autophagy and senescence

Sebastien Cagnol, Jean‐Claude Chambard

The FEBS Journal > 277 > 1 > 2 - 21

The Ras/Raf/extracellular signal‐regulated kinase (ERK) signaling pathway plays a crucial role in almost all cell functions and therefore requires exquisite control of its spatiotemporal activity. Depending on the cell type and stimulus, ERK activity will mediate different antiproliferative events, such as apoptosis, autophagy and senescence in vitro and in vivo. ERK activity can promote either intrinsic...

article

Membrane anchoring of diacylglycerol lactones substituted with rigid hydrophobic acyl domains correlates with biological activities

Or Raifman, Sofiya Kolusheva, Maria J. Comin, Noemi Kedei, more

The FEBS Journal > 277 > 1 > 233 - 243

Synthetic diacylglycerol lactones (DAG lactones) are effective modulators of critical cellular signaling pathways downstream of the lipophilic second messenger diacylglycerol that activate a host of protein kinase C (PKC) isozymes as well as other non‐kinase proteins that share with PKC similar C1 membrane‐targeting domains. A fundamental determinant of the biological activity of these amphiphilic...

article

Mucin‐type O‐glycosylation – putting the pieces together

Pia H. Jensen, Daniel Kolarich, Nicolle H. Packer

The FEBS Journal > 277 > 1 > 81 - 94

The O‐glycosylation of Ser and Thr by N‐acetylgalactosamine‐linked (mucin‐type) oligosaccharides is often overlooked in protein analysis. Three characteristics make O‐linked glycosylation more difficult to analyse than N‐linked glycosylation, namely: (a) no amino acid consensus sequence is known; (b) there is no universal enzyme for the release of O‐glycans from the protein backbone; and (c) the density...

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Neuropeptide Y expression and function during osteoblast differentiation – insights from transthyretin knockout mice

Ana F. Nunes, Márcia A. Liz, Filipa Franquinho, Liliana Teixeira, more

The FEBS Journal > 277 > 1 > 263 - 275

To better understand the role of neuropeptide Y (NPY) in bone homeostasis, as its function in the regulation of bone mass is unclear, we assessed its expression in this tissue. By immunohistochemistry, we demonstrated, both at embryonic stages and in the adult, that NPY is synthesized by osteoblasts, osteocytes, and chondrocytes. Moreover, peptidylglycine α‐amidating monooxygenase, the enzyme responsible...

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Different roles of functional residues in the hydrophobic binding site of two sweet orange tau glutathione S‐transferases

Angela R. Lo Piero, Valeria Mercurio, Ivana Puglisi, Goffredo Petrone

The FEBS Journal > 277 > 1 > 255 - 262

Glutathione S‐transferases (GSTs) catalyze the conjugation of glutathione to hydrophobic compounds, contributing to the metabolism of toxic chemicals. In this study, we show that two naturally occurring tau GSTs (GSTUs) exhibit distinctive kinetic parameters towards 1‐chloro‐2,4‐dinitrobenzene (CDNB), although they differ only in three amino acids (Arg89, Glu117 and Ile172 in GSTU1 are replaced by...

article

Small peptides derived from the Lys active fragment of the mung bean trypsin inhibitor are fully active against trypsin

Rui‐Feng Qi, Zhi‐Xue Liu, Shao‐Qiong Xu, Ling Zhang, more

The FEBS Journal > 277 > 1 > 224 - 232

The Bowman–Birk protease inhibitors have recently attracted attention for their potential as cancer preventive and suppressing agents. They contain two canonical binding loops, both consisting of nine highly conserved residues capable of inhibiting corresponding serine proteases. In this study, we cloned the cDNA of the mung bean trypsin inhibitor, one of the most studied Bowman–Birk protease inhibitors...

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Temporal expression of heat shock genes during cold stress and recovery from chill coma in adult Drosophila melanogaster

Hervé Colinet, Siu Fai Lee, Ary Hoffmann

The FEBS Journal > 277 > 1 > 174 - 185

A common physiological response of organisms to environmental stresses is the increase in expression of heat shock proteins (Hsps). In insects, this process has been widely examined for heat stress, but the response to cold stress has been far less studied. In the present study, we focused on 11 Drosophila melanogaster Hsp genes during the stress exposure and recovery phases. The temporal gene expression...

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The FEBS Journal

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The transcriptome of the colonial marine hydroid Hydractinia echinata

Binase cleaves cellular noncoding RNAs and affects coding mRNAs

Death‐associated protein kinase (DAPK) and signal transduction

Death‐associated protein kinase (DAPK) and signal transduction: blebbing in programmed cell death

ERK and cell death: ERK1/2 in neuronal death

Author index

ERK and cell death: Mechanisms of ERK‐induced cell death – apoptosis, autophagy and senescence

Membrane anchoring of diacylglycerol lactones substituted with rigid hydrophobic acyl domains correlates with biological activities

Mucin‐type O‐glycosylation – putting the pieces together

Neuropeptide Y expression and function during osteoblast differentiation – insights from transthyretin knockout mice

Different roles of functional residues in the hydrophobic binding site of two sweet orange tau glutathione S‐transferases

Small peptides derived from the Lys active fragment of the mung bean trypsin inhibitor are fully active against trypsin

Temporal expression of heat shock genes during cold stress and recovery from chill coma in adult Drosophila melanogaster

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