Search results for: Carole Evelegh

Items from 1 to 7 out of 7 results

article

Designed ankyrin repeat proteins are effective targeting elements for chimeric antigen receptors

Joanne A. Hammill, Heather VanSeggelen, Christopher W. Helsen, Galina F. Denisova, more

Journal for ImmunoTherapy of Cancer > 2015 > 3 > 1 > 1-11

Background Adoptive cell transfer of tumor-specific T lymphocytes (T cells) is proving to be an effective strategy for treating established tumors in cancer patients. One method of generating these cells is accomplished through engineering bulk T cell populations to express chimeric antigen receptors (CARs), which are specific for tumor antigens. Traditionally, these CARs are targeted against tumor...

article

On-target off-tumor toxicity; when enhancing an NKG2D-based CAR in vitro led to severe toxicities in vivo

Heather VanSeggelen, Joanne A Hammill, Daniela Gm Tantalo, Carole Evelegh, more

Journal for ImmunoTherapy of Cancer > 2014 > 2 > 3 > 1-1

article

Novel method for differentiation between Trastuzumab and host adaptive response

Galina Denisova, Kristina Jenkins, Carole Evelegh, Jonathan Bramson

Molecular Immunology > 2011 > 48 > 15-16 > 1882-1885

Humoral immune response to human epidermal growth factor receptor 2 (HER-2/neu or ErbB-2) has been detected in sera of breast cancer patients and shown to be an appropriate prognostic marker (Taylor et al., 2007). However, since Trastuzumab (Herceptin) is a widely used monoclonal antibody as cancer therapy agent for tumors over-expressing HER-2, there is a need for an efficient way to detect host-generated...

article

The magnitude of the CD8+ T cell response produced by recombinant virus vectors is a function of both the antigen and the vector

James Millar, Dilan Dissanayake, Teng Chih Yang, Natalie Grinshtein, more

Cellular Immunology > 2007 > 250 > 1-2 > 55-67

Virus-based recombinant vaccines have proven highly effective at generating protective CD8+ T cell responses. Multiple vector platforms are available, however, little is known about the relative influence of the different vectors on the transgene-specific CD8+ T cell population. To address this question, we compared several characteristics of the CD8+ T cell response elicited by recombinant adenovirus...

article

Semliki Forest virus and Kunjin virus RNA replicons elicit comparable cellular immunity but distinct humoral immunity

Laura Lee Tannis, Andree Gauthier, Carole Evelegh, Robin Parsons, more

Vaccine > 2005 > 23 > 33 > 4189-4194

RNA replicons offer a number of qualities which make them attractive as vaccination vectors. Both alphavirus and flavivirus replicon vaccines have been investigated in preclinical models yet there has been little direct comparison of the two vector systems. To determine whether differences in the biology of the two vectors influence immunogenicity, we compared two prototypic replicon vectors based...

article

Development of a FLP/frt System for Generating Helper-Dependent Adenoviral Vectors

Philip Ng, Cindy Beauchamp, Carole Evelegh, Robin Parks, more

Molecular Therapy > 2001 > 3 > 5 > 809-815

Helper-dependent (HD) adenoviral vectors devoid of all viral coding sequences have a large cloning capacity and have been reported to provide long-term transgene expression in vivo with negligible toxicity, making them attractive vectors for gene therapy. Currently, the most efficient means of generating HD vectors involves co-infecting 293 cells expressing Cre with the HD vector and a helper virus...

article

Cloning and Sequencing of the Cellular–Viral Junctions from the Human Adenovirus Type 5 Transformed 293 Cell Line

Nathalie Louis, Carole Evelegh, Frank L. Graham

Virology > 1997 > 233 > 2 > 423-429

The human–viral junctions of integrated adenovirus type 5 (Ad5) DNA in 293 cells have been cloned and sequenced. The Ad5 sequences extend from nucleotides (nt) 1 to 4344 and are located in the pregnancy-specific β-1-glycoprotein 4 (PSG 4) gene. This maps the insertion of Ad5 DNA to human chromosome 19 (19q13.2). The Ad5 sequences are represented as a single collinear insertion of viral DNA with no...

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Search results for: Carole Evelegh

Designed ankyrin repeat proteins are effective targeting elements for chimeric antigen receptors

On-target off-tumor toxicity; when enhancing an NKG2D-based CAR in vitro led to severe toxicities in vivo

Novel method for differentiation between Trastuzumab and host adaptive response

The magnitude of the CD8+ T cell response produced by recombinant virus vectors is a function of both the antigen and the vector

Semliki Forest virus and Kunjin virus RNA replicons elicit comparable cellular immunity but distinct humoral immunity

Development of a FLP/frt System for Generating Helper-Dependent Adenoviral Vectors

Cloning and Sequencing of the Cellular–Viral Junctions from the Human Adenovirus Type 5 Transformed 293 Cell Line

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