Search results for: Masaki Ishikawa

Items from 1 to 20 out of 57 results

article

Reproducible preclinical models of androgen receptor driven human prostate cancer bone metastasis

JuanJuan Yin, Asha Daryanani, Fan Lu, Anson T. Ku, more

Background Preclinical models recapitulating the metastatic phenotypes are essential for developing the next‐generation therapies for metastatic prostate cancer (mPC). We aimed to establish a cohort of clinically relevant mPC models, particularly androgen receptor positive (AR⁺) bone metastasis models, from LuCaP patient‐derived xenografts (PDX) that reflect the heterogeneity and complexity of mPC...

article

Indoleamine 2,3‐dioxygenase 2 deficiency associates with autism‐like behavior via dopaminergic neuronal dysfunction

Masaki Ishikawa, Yasuko Yamamoto, Bolati Wulaer, Kazuo Kunisawa, more

The FEBS Journal > 291 > 5 > 945 - 964

Indoleamine 2,3‐dioxygenase 2 (IDO2) is an enzyme of the tryptophan–kynurenine pathway that is constitutively expressed in the brain. To provide insight into the physiological role of IDO2 in the brain, behavioral and neurochemical analyses in IDO2 knockout (KO) mice were performed. IDO2 KO mice showed stereotyped behavior, restricted interest and social deficits, traits that are associated with behavioral...

article

An ABCB transporter regulates anisotropic cell expansion via cuticle deposition in the moss Physcomitrium patens

Liechi Zhang, Yuko Sasaki‐Sekimoto, Ken Kosetsu, Tsuyoshi Aoyama, more

New Phytologist > 241 > 2 > 665 - 675

Anisotropic cell expansion is crucial for the morphogenesis of land plants, as cell migration is restricted by the rigid cell wall. The anisotropy of cell expansion is regulated by mechanisms acting on the deposition or modification of cell wall polysaccharides. Besides the polysaccharide components in the cell wall, a layer of hydrophobic cuticle covers the outer cell wall and is subjected to tensile...

article

Muscle‐tendon architecture in Kenyans and Japanese: Potential role of genetic endowment in the success of elite Kenyan endurance runners

Yoko Kunimasa, Kanae Sano, Toshiaki Oda, Caroline Nicol, more

Acta Physiologica > 235 > 2 > n/a - n/a

Aim The specificity of muscle‐tendon and foot architecture of elite Kenyan middle‐ and long‐distance runners has been found to contribute to their superior running performance. To investigate the respective influence of genetic endowment and training on these characteristics, we compared leg and foot segmental lengths as well as muscle‐tendon architecture of Kenyans and Japanese males (i) from infancy...

article

Plant stem cell research is uncovering the secrets of longevity and persistent growth

Masaaki Umeda, Momoko Ikeuchi, Masaki Ishikawa, Toshiro Ito, more

The Plant Journal > 106 > 2 > 326 - 335

Plant stem cells have several extraordinary features: they are generated de novo during development and regeneration, maintain their pluripotency, and produce another stem cell niche in an orderly manner. This enables plants to survive for an extended period and to continuously make new organs, representing a clear difference in their developmental program from animals. To uncover regulatory principles...

article

Usefulness of Amplatzer Vascular Plug for Preoperative Embolization Before Distal Pancreatectomy with En Bloc Celiac Axis Resection

Tomoyo Fuji, Takuji Yamagami, Wataru Fukumoto, Yasutaka Baba, more

CardioVascular and Interventional Radiology > 2019 > 42 > 9 > 1352-1357

Purpose We evaluated the usefulness of the Amplatzer vascular plug (AVP) for preoperative embolization before distal pancreatectomy with en bloc celiac axis resection (DP-CAR). Materials and Methods Between April 2010 and September 2017, 19 patients with locally advanced pancreatic body cancer underwent preoperative embolization of the common hepatic and the left gastric artery (CHA, LGA) with AVP...

article

Correction to: Protective and therapeutic role of 2-carbacyclic phosphatidic acid in demyelinating disease

Shinji Yamamoto, Kota Yamashina, Masaki Ishikawa, Mari Gotoh, more

Journal of Neuroinflammation > 2018 > 15 > 1 > 1-1

After publication of the article [1], it was brought to our attention that an acknowledgement was missing from the original version.

article

The flavonoid Baicalein attenuates cuprizone-induced demyelination via suppression of neuroinflammation

Miho Hashimoto, Shinji Yamamoto, Kensuke Iwasa, Kota Yamashina, more

Brain Research Bulletin > 2017 > 135 > C > 47-52

Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system characterized by recurrent and progressive demyelination/remyelination cycles, neuroinflammation, oligodendrocyte loss, and axonal pathology. Baicalein isolated from the roots of Scutellaria baicalensis has been shown to exert anti-inflammatory and antioxidant effects. The cuprizone model is an established mouse...

article

Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease

Shinji Yamamoto, Kota Yamashina, Masaki Ishikawa, Mari Gotoh, more

Journal of Neuroinflammation > 2017 > 14 > 1 > 1-14

Background Multiple sclerosis is a neuroinflammatory demyelinating and neurodegenerative disease of the central nervous system characterized by recurrent and progressive demyelination/remyelination cycles, neuroinflammation, oligodendrocyte loss, demyelination, and axonal degeneration. Cyclic phosphatidic acid (cPA) is a natural phospholipid mediator with a unique cyclic phosphate ring structure at...

article

F-spondin negatively regulates dental follicle differentiation through the inhibition of TGF-β activity

Ai Orimoto, Misaki Kurokawa, Keisuke Handa, Masaki Ishikawa, more

Archives of Oral Biology > 2017 > 79 > C > 7-13

F-spondin is an extracellular matrix (ECM) protein that belongs to the thrombospondin type I repeat superfamily and is a negative regulator of bone mass. We have previously shown that f-spondin is specifically expressed in the dental follicle (DF), which gives rise to the periodontal ligament (PDL) during the tooth root formation stage. To investigate the molecular mechanism of PDL formation, we investigated...

article

Plasma lipid profiling of chemical-induced liver injuries

Kosuke Saito, Masaki Ishikawa, Hiroshi Yamada, Noriyuki Nakatsu, more

Drug Metabolism and Pharmacokinetics > 2017 > 32 > 1 Supplement > S33

article

Neuromechanical Modulation of the Achilles Tendon During Bilateral Hopping in Patients with Unilateral Achilles Tendon Rupture, Over 1 Year After Surgical Repair

Hiroyuki Oda, Kanae Sano, Yoko Kunimasa, Paavo V. Komi, more

Sports Medicine > 2017 > 47 > 6 > 1221-1230

Background Patients who have had an Achilles tendon (AT) rupture repaired are potentially at higher risk for re-rupture than those without previous rupture. Little attention has been given to the neuromechanical modulation of muscle–tendon interaction and muscle activation profiles during human dynamic movements after AT rupture repair. Objective The purpose of this study was to examine muscle–tendon...

chapter

Method of Beam Energy Adjustment by Using Beam Parallelism

Haruka Sasaki, Hiroyuki Kariya, Masaki Ishikawa, Michiro Sugitani

2016 21st International Conference on Ion Implantation Technology (IIT) > 1 - 4

2016 21st International Conference on Ion Implantation Technology (IIT)

As the market for high quality image sensors expands so has the importance of ultra-high energy ion implant. Critical implanter features include beam energy adjustment and precise beam angle control. For implant energy exceeding several MeV, only a few percent error produces several tens of keV energy difference, which means the implant depth varies several tens of nm. Sumitomo Heavy Industries Ion...

article

Blood Flow Redistribution Using the AMPLATZER Vascular Plug 4 before Distal Pancreatectomy with en Bloc Celiac Axis Resection

Masaki Ishikawa, Kenji Kajiwara, Wataru Fukumoto, Yoshiaki Murakami, more

Journal of Vascular and Interventional Radiology > 2016 > 27 > 2 > 285-286

article

Embolization for type 2 endoleak with sac expansion after endovascular repair of abdominal aortic aneurysm: safety and effectiveness

Kenji Kajiwara, Takuji Yamagami, Masaki Urashima, Hideki Tomiyoshi, more

SpringerPlus > 2016 > 5 > 1 > 1-7

To evaluate the safety and outcome of embolization as treatment for persistent type 2 endoleak (T2EL) occurring after abdominal aortic stent graft implantation. This retrospective study included seven consecutive patients (one female, six males, mean age 72 years, range 66–88 years) with T2EL between January 2011 and September 2012. In all, T2EL was associated with an increase more than 5 mm in the...

article

Change in Imaging Findings on Angiography-Assisted CT During Balloon-Occluded Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma

Rika Yoshimatsu, Takuji Yamagami, Masaki Ishikawa, Kenji Kajiwara, more

CardioVascular and Interventional Radiology > 2016 > 39 > 6 > 865-874

Purpose To evaluate changes in imaging findings on CT during hepatic arteriography (CTHA) and CT during arterial portography (CTAP) by balloon occlusion of the treated artery and their relationship with iodized oil accumulation in the tumor during balloon-occluded transcatheter arterial chemoembolization (B-TACE). Methods Both B-TACE and angiography-assisted CT were performed for 27 hepatocellular...

article

Plasma lipid profiling of different types of hepatic fibrosis induced by carbon tetrachloride and lomustine in rats

Masaki Ishikawa, Kosuke Saito, Hiroshi Yamada, Noriyuki Nakatsu, more

Lipids in Health and Disease > 2016 > 15 > 1 > 1-10

Background Plasma lipid profiling has emerged as a useful tool for understanding the pathophysiology of hepatic injury and disease. Hepatic fibrosis results from chronic, progressive damage to the liver and can lead, in turn, to more serious conditions such as hepatic cirrhosis and hepatocellular carcinoma. Thus, the present study aimed to investigate the plasma lipid profiles of two types of hepatic...

article

Practical Tantalum Coating of Microspheres for Experimental Visualization under Fluoroscopy and CT

Masahiro Horikawa, Masaki Ishikawa, Barry T. Uchida, John A. Kaufman, more

Journal of Vascular and Interventional Radiology > 2016 > 27 > 1 > 127-132

The present report describes a simple technique for tantalum coating of microspheres for visualization by fluoroscopy and computed tomography (CT). Spherical microspheres were soaked with Ta powder under different conditions and microscopically evaluated for Ta-coating quality by assessing bound and unbound Ta. For 100–300-µm Embosphere particles, soaking with 0.05 mL Ta powder for 30 minutes and...

article

Cell cycle reentry from the late S phase: implications from stem cell formation in the moss Physcomitrella patens

Masaki Ishikawa, Mitsuyasu Hasebe

Journal of Plant Research > 2015 > 128 > 3 > 399-405

Differentiated cells are in a non-dividing, quiescent state, but some differentiated cells can reenter the cell cycle in response to appropriate stimuli. Quiescent cells are generally arrested at the G0/G1 phase, reenter the cell cycle, and progress to the S phase to replicate their genomic DNA. On the other hand, some types of cells are arrested at the different phase and reenter the cell...

article

Neuromuscular mechanics and hopping training in elderly

Merja Hoffrén-Mikkola, Masaki Ishikawa, Timo Rantalainen, Janne Avela, more

European Journal of Applied Physiology > 2015 > 115 > 5 > 863-877

Purpose The present study examined the effects of repetitive hopping training on muscle activation profiles and fascicle–tendon interaction in the elderly. Methods 20 physically active elderly men were randomly assigned for training (TG) and control groups (CG). TG performed supervised bilateral short contact hopping training with progressively increasing training volume. Measurements...

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INFONA - science communication portal

Search results for: Masaki Ishikawa

Reproducible preclinical models of androgen receptor driven human prostate cancer bone metastasis

Indoleamine 2,3‐dioxygenase 2 deficiency associates with autism‐like behavior via dopaminergic neuronal dysfunction

An ABCB transporter regulates anisotropic cell expansion via cuticle deposition in the moss Physcomitrium patens

Muscle‐tendon architecture in Kenyans and Japanese: Potential role of genetic endowment in the success of elite Kenyan endurance runners

Plant stem cell research is uncovering the secrets of longevity and persistent growth

Usefulness of Amplatzer Vascular Plug for Preoperative Embolization Before Distal Pancreatectomy with En Bloc Celiac Axis Resection

Correction to: Protective and therapeutic role of 2-carbacyclic phosphatidic acid in demyelinating disease

The flavonoid Baicalein attenuates cuprizone-induced demyelination via suppression of neuroinflammation

Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease

F-spondin negatively regulates dental follicle differentiation through the inhibition of TGF-β activity

Plasma lipid profiling of chemical-induced liver injuries

Neuromechanical Modulation of the Achilles Tendon During Bilateral Hopping in Patients with Unilateral Achilles Tendon Rupture, Over 1 Year After Surgical Repair

Method of Beam Energy Adjustment by Using Beam Parallelism

Blood Flow Redistribution Using the AMPLATZER Vascular Plug 4 before Distal Pancreatectomy with en Bloc Celiac Axis Resection

Embolization for type 2 endoleak with sac expansion after endovascular repair of abdominal aortic aneurysm: safety and effectiveness

Change in Imaging Findings on Angiography-Assisted CT During Balloon-Occluded Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma

Plasma lipid profiling of different types of hepatic fibrosis induced by carbon tetrachloride and lomustine in rats

Practical Tantalum Coating of Microspheres for Experimental Visualization under Fluoroscopy and CT

Cell cycle reentry from the late S phase: implications from stem cell formation in the moss Physcomitrella patens

Neuromuscular mechanics and hopping training in elderly

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