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The delivery of gadolinium through the ultrasound- induced blood-brain barrier (BBB) openings of mice was investigated. The left hippocampus of mice (n=13) was sonicated (frequency: 1.525 MHz, pressure amplitude: 0.64 MPa, duty cycle: 20%, duration: 1 minute) in vivo through the intact skin and skull after the injection of pre-formed microbubbles (SonoVuereg; 25-30 mul). The BBB opening in mice was...
Most neurologically potent drugs cannot be delivered to the brain because of its distinct vasculature: the blood-brain barrier (BBB). Focused ultrasound (FUS) has been shown to produce reversible and localized BBB opening when applied in the presence of microbubbles [Hynynen, K, 2001]. In this study, the dependence of microbubble concentration and vessel type distribution in the targeted brain region...
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