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The entorhinal cortex (EC) is affected early in Alzheimer's disease, an illness defined by a co-occurrence of tau and amyloid-related pathologies. How the co-occurrence of these pathologies in the EC affects the hippocampal circuit remains unknown. Here we address this question by performing electrophysiological analyses of the EC circuit in mice that express mutant human amyloid precursor protein...
Most neurologically potent drugs cannot be delivered to the brain because of its distinct vasculature: the blood-brain barrier (BBB). Focused ultrasound (FUS) has been shown to produce reversible and localized BBB opening when applied in the presence of microbubbles [Hynynen, K, 2001]. In this study, the dependence of microbubble concentration and vessel type distribution in the targeted brain region...
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