Search results for: M. Molle

Items from 1 to 18 out of 18 results

article

Nanoparticles for vaccine and gene therapy: Overcoming the barriers to nucleic acid delivery

Lara M. Mollé, Cameron H. Smyth, Daniel Yuen, Angus P. R. Johnston

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology > 14 > 6 > n/a - n/a

Nucleic acid therapeutics can be used to control virtually every aspect of cell behavior and therefore have significant potential to treat genetic disorders, infectious diseases, and cancer. However, while clinically approved to treat a small number of diseases, the full potential of nucleic acid therapeutics is hampered by inefficient delivery. Nucleic acids are large, highly charged biomolecules...

article

The expression of P2Y₆ receptor promotes the quality of mucus in colitic mice

Morgane Placet, Caroline M. Molle, Guillaume Arguin, Sameh Geha, more

The FEBS Journal > 288 > 18 > 5459 - 5473

In the intestine, mucins are expressed and secreted by goblet cells and enterocytes in a constitutive manner and in response to secretagogues to form a protective mucus layer. This protective barrier is often lost in inflammatory bowel disease (IBD). Interestingly, extracellular nucleotides, through P2Y receptors, were identified as mucin secretagogues in mucinous epithelia. These nucleotides are...

article

Expression and function of the P2X7 receptor in human osteoblasts: The role of NFATc1 transcription factor

Leticia Scussel Bergamin, Letizia Penolazzi, Elisabetta Lambertini, Simonetta Falzoni, more

Journal of Cellular Physiology > 236 > 1 > 641 - 652

Bone mineralization is an orchestrated process by which mineral crystals are deposited by osteoblasts; however, the detailed mechanisms remain to be elucidated. The presence of P2X7 receptor (P2X7R) in immature and mature bone cells is well established, but contrasting evidence on its role in osteogenic differentiation and deposition of calcified bone matrix remains. To clarify these controversies...

article

The G protein-coupled P2Y6 receptor promotes colorectal cancer tumorigenesis by inhibiting apoptosis

Morgane Placet, Guillaume Arguin, Caroline M. Molle, Jean-Philippe Babeu, more

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease > 2018 > 1864 > 5(PA) > 1539-1551

Colorectal tumors are immersed in an array of tumor-promoting factors including extracellular nucleotides such as uridine 5′‑diphosphate (UDP). UDP is the endogenous agonist of the G protein-coupled P2Y₆ receptor (P2Y₆R), which may contribute to the formation of a tumor-promoting microenvironment by coordinating resistance to apoptosis. Colorectal cancer (CRC) was chemically induced in P2ry6 knockout...

article

Eczema‐like fish tank granuloma: a new clinical presentation of Mycobacterium marinum infection

S. Veraldi, M. Molle, G. Nazzaro

Journal of the European Academy of Dermatology and Venereology > 32 > 5 > e200 - e201

chapter

Efficient computation of queueing delay at a network port from output link packet traces

M F Habib, M Molle

2010 22nd International Teletraffic Congress (lTC 22) > 1 - 8

2010 22nd International Teletraffic Congress (ITC 22)

Current Internet core routers provide enough buffer capacity at each output port to keep the link busy for 250 msec. to avoid disrupting TCP flows because of dropped packets. Since link speeds are rising much more quickly than the availability and cost-effectiveness of large high-speed memories, there is now significant interest in reducing these buffers. Queue inferencing (QI) - a passive, external...

article

Slow-oscillatory transcranial direct current stimulation can induce bidirectional shifts in motor cortical excitability in awake humans

S. Groppa, T.O. Bergmann, C. Siems, M. Mölle, more

Neuroscience > 2010 > 166 > 4 > 1219-1225

Constant transcranial direct stimulation (c-tDCS) of the primary motor hand area (M1 _HAND ) can induce bidirectional shifts in motor cortical excitability depending on the polarity of tDCS. Recently, anodal slow oscillation stimulation at a frequency of 0.75 Hz has been shown to augment intrinsic slow oscillations during sleep and theta oscillations during wakefulness. To embed this new type...

chapter

Localization and clock synchronization need similar hardware support in wireless LANs

S. Parichha, M. Molle

2008 IEEE International Symposium on Precision Clock Synchronization for Measurement, Control and Communication > 131 - 136

2008 IEEE International Symposium on Precision Clock Synchronization for Measurement, Control and Communication

Secure localization protocols enable a group of cooperating verifier nodes in a wireless LAN to determine the physical location of a stranger (called the prover), using precision timing measurements during a carefully scripted packet exchange. After identifying a number of common features between the localization and precision clock synchronization problems, we describe a small set of additional physical-layer...

article

Signs of impaired selective attention in patients with amyotrophic lateral sclerosis

E. H. Pinkhardt, R. Jürgens, W. Becker, M. Mölle, more

Journal of Neurology > 2008 > 255 > 4 > 532-538

The evidence for involvement of extramotor cortical areas in non-demented patients with amyotrophic lateral sclerosis (ALS) has been provided by recent neuropsychological and functional brain imaging studies. The aim of this study was to investigate possible alterations in selective attention, as an important constituent part of frontal brain function in ALS patients. A classical dichotic listening...

chapter

CAM04-3: Optimal Routing Between Alternate Paths With Different Network Transit Delays

E.H. Elhafsi, M. Molle

IEEE Globecom 2006 > 1 - 5

IEEE Globecom 2006

We consider the path-determination problem in Internet core routers that distribute flows across alternate paths leading to the same destination. We assume that the remainder of the network transit delay beyond this router are different for the two paths, so a good routing policy can reduce the end-to-end delay by favoring the faster path. Thus, we propose and solve the optimal path-determination...

chapter

A Comprehensive Comparison of Routing Protocols for Large-Scale Wireless MANETs

I. Broustis, G. Jakllari, T. Repantis, M. Molle

2006 3rd Annual IEEE Communications Society on Sensor and Ad Hoc Communications and Networks > 3 > 951 - 956

2006 3rd Annual IEEE Communications Society Conference on Sensor and Ad Hoc Communications and Networks

Efficient routing protocols can provide significant benefits to mobile ad hoc networks, in terms of both performance and reliability. Many routing protocols for such networks have been proposed so far. Amongst the most popular ones are dynamic source routing (DSR), ad hoc on-demand distance vector (AODV), temporally-ordered routing algorithm (TORA) and location-aided routing (LAR). Despite the popularity...

article

Evidence for anisotropic atomic displacements and orbital distribution in the inhomogeneous CuO ₂ plane of the Bi ₂ Sr ₂ CaCu ₂ O ₈ ₊ _δ system

N.L. Saini, H. Oyanagi, M. Molle, K.B. Garg, more

Journal of Physics and Chemistry of Solids > 2004 > 65 > 8-9 > 1439-1443

We have used a combination of the Cu K-edge extended X-ray absorption fine structure (EXAFS), and the Cu L-edge X-ray absorption measurements, with polarization vector parallel to the two orthogonal Cu-O-Cu bonds, to explore the directional instantaneous atomic displacements and the orbital distribution within the heterogeneaous CuO ₂ plane of the Bi ₂ Sr ₂ CaCu ₂ O...

chapter

A nonstationary Poisson view of Internet traffic

T. Karagiannis, M. Molle, M. Faloutsos, A. Broido

IEEE INFOCOM 2004 > 3 > 1558 - 1569 vol.3

IEEE INFOCOM 2004

Since the identification of long-range dependence in network traffic ten years ago, its consistent appearance across numerous measurement studies has largely discredited Poisson-based models. However, since that original data set was collected, both link speeds and the number of Internet-connected hosts have increased by more than three orders of magnitude. Thus, we now revisit the Poisson assumption,...

article

Spindle and slow wave rhythms at slow wave sleep transitions are linked to strong shifts in the cortical direct current potential

L. Marshall, M. Mölle, J. Born

Neuroscience > 2003 > 121 > 4 > 1047-1053

Electroencephalographic activity at the transition from wakefulness to sleep is characterized by the appearance of spindles (12-15 Hz) and slow wave rhythms including delta activity (1-4 Hz) and slow oscillations (0.2-1 Hz). While these rhythms originate within neocortico-thalamic circuitry, their emergence during the passage into slow wave sleep (SWS) critically depends on the activity of neuromodulatory...

article

EEG synchronization upon reward in man

M. Hallschmid, M. Mölle, S. Fischer, J. Born

Clinical Neurophysiology > 2002 > 113 > 7 > 1059-1065

Objectives: It was tested whether reward in humans is associated with EEG synchronization similar to that seen in animals.Methods: In two experiments (I and II) the EEG was recorded from frontal, central, and parietal positions before, during, and after drinking or oral stimulation. In Experiment I, subjects (n=11) who had either been thirsty for 16h or had quenched thirst before recordings, drank...

article

Drinking related direct current positive potential shift in the human EEG depends on thirst

M Hallschmid, M Mölle, U Wagner, H.L Fehm, more

Neuroscience Letters > 2001 > 311 > 3 > 173-176

Scalp recorded direct current (DC)-potential shifts were examined in 11 human subjects who had either thirsted for 16 h or had quenched thirst before recordings. The recording epoch included a 3-min baseline, an interval of about 5 min during which subjects drank 400 ml of water, and a 7-min post-drinking interval. Consistent with previous data, when thirsty, subjects displayed a widespread negative...

article

Experimental study of ternary M-Zn-Se (M = W, Au, In, Ti) phase equilibria

R. Schmid-Fetzer, R. Schwarz, M. Mölle, T. Studnitzky, more

Journal of Alloys and Compounds > 1997 > 247 > 1-2 > 158-163

Ternary phase equilibria in the systems M-Zn-Se (M = W, Au, In, Ti) are studied by X-ray diffraction on samples annealed in silica capsules and quenched. Four isothermal phase diagram sections are presented and discussed. Only in the In-Zn-Se system a ternary compound is present (ZnIn ₂ Se ₄ ). The metals W, Au and In are in equilibrium with the II-VI semiconductor ZnSe, whereas Ti...

article

Sensory processing during early and late nocturnal sleep

W. Plihal, S. Weaver, M. Mölle, H.L. Fehm, more

Electroencephalography and Clinical Neurophysiology > 1996 > 99 > 3 > 247-256

The present experiments in 10 healthy men compared auditory evoked potentials (AEPs) and heart rate (HR) indicators of stimulus processing during early and late phases of nocturnal stage 2 sleep. Definition of early and late sleep relied on endocrine pituitary-adrenal secretory activity which is known to be inhibited during early nocturnal sleep but sharply increases during late sleep. AEPs and...

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