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We have investigated the HLA-B27-restricted CTL response to HY minor histocompatibility antigens in rats and mice transgenic for HLA-B27 and human β2-microglobulin. A polymorphism was found at a locus within the H2 complex, producing two distinct but overlapping sets of B27-presented HY peptides. The locus, named Cim2, mapped between the K and Pb loci, and its product is therefore distinct from TAP,...
Human cytomegalovirus (HCMV) inhibits MHC class I antigen presentation by a sequential multistep process involving a family of unique short (US) region-encoded glycoproteins. US3 retains class I molecules, whereas US2 and US11 mediate the cytosolic degradation of heavy chains by the proteosomes. In US6-transfected cells, however, intracellular transport of class I molecules is impaired because of...
Introduction: In cells infected with human cytomegalovirus (HCMV) down-regulation of MHC class I expression is observed. In the absence of functional MHC class I complexes, the infected cells will escape from destruction by cytotoxic T cells. Surprisingly, HCMV achieves this goal by multiple strategies involving different gene products. Four of these gene products, US2, US3, US6 and US11, were...
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