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Introduction: The IgA Fc receptor (CD89) is expressed on several types of cells of the myeloid cell-lineage. We investigated whether different sizes of heat-aggregated IgA (algA) bind to CD89 and subsequently induce cellular activation.Materials & Methods: As a model we used the murine B cell line IIA1.6 transfected with CD89 or IIA1.6 cells transfected with CD89 as well as with the FcR γ-chain...
Introduction: Primary IgA nephropathy (IgAN) is associated with elevated IgA concentrations in the serum and characterized by depositions of polymeric IgA (pIgA) in the renal mesangium, Recently, the gene for the human myeloid FcαR, CD89, has been cloned. CD89 expression has been demonstrated on mesangial cells in vitro. Therefore CD89 might be involved in disease associated IgA deposition, either...
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