Search results for: Brinell Arcanjo Moura

Items from 1 to 12 out of 12 results

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Antidepressant‐like effect of bis‐eugenol in the mice forced swimming test: evidence for the involvement of the monoaminergic system

Jeferson Falcão do Amaral, Maria Izabel Gomes Silva, Manuel Rufino de Aquino Neto, Brinell Arcanjo Moura, more

Fundamental & Clinical Pharmacology > 27 > 5 > 471 - 482

Dehydrodieugenol, known as bis‐eugenol, is a eugenol ortho dimer, and both compounds were able to exhibit anti‐inflammatory and antioxidant activities in previous studies. Furthermore, eugenol showed antidepressant‐like effect; however, the biological actions of bis‐eugenol on experimental models for screening antidepressant activity are still unknown. The present study investigated a possible antidepressant‐like...

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Evidence for the involvement of the serotonergic, noradrenergic, and dopaminergic systems in the antidepressant‐like action of riparin III obtained from Aniba riparia (Nees) Mez (Lauraceae) in mice

Carla Thiciane Vasconcelos Melo, Alyne Mara Rodrigues de Carvalho, Brinell Arcanjo Moura, Caroline Porto Leite Teixeira, more

Fundamental & Clinical Pharmacology > 27 > 1 > 104 - 112

Previous work has shown that intraperitoneal administration of riparin III (ripIII) reduces immobility time in the forced swimming test (FST), which suggests potential antidepressant activity. As the mechanism of action is not completely understood, this study is aimed at investigating the antidepressant‐like action of ripIII. Following intraperitoneal administration of ripIII at doses of 25 and 50...

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Reversal of cocaine withdrawal-induced anxiety by ondansetron, buspirone and propranolol

Maria do Carmo de Oliveira Citó, Francisca Charliane Carlos da Silva, Maria Izabel Gomes Silva, Brinell Arcanjo Moura, more

Behavioural Brain Research > 2012 > 231 > 1 > 116-123

Cocaine is used worldwide and considered a public health problem. Relapse from addiction is one of the difficulties faced by cocaine users, and in most cases according to the period of abstinence, users may present symptoms such as anxiety or depression. To evaluate the anxiety-like behavior induced by different periods, rats were treated for 7 days with cocaine 20mg/kg, i.p., and 24h, 7 and 21 days...

article

Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice

Gilberto Santos Cerqueira, Gabriela dos Santos e Silva, Emiliano Rios Vasconcelos, Ana Paula Fragoso de Freitas, more

European Journal of Pharmacology > 2012 > 683 > 1-3 > 260-269

This study investigates the gastroprotective effects of hecogenin, a steroid saponin isolated from Agave sisalana, on experimental models of gastric ulcer. Male Swiss mice were used in the models of ethanol- and indometacin-induced gastric ulcer. To clarify the hecogenin mechanism of action, the roles of nitric oxide (NO), sulfhydryls (GSH), K ⁺ _ATP channels and prostaglandins were also...

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Antidepressant‐like effect of carvacrol (5‐Isopropyl‐2‐methylphenol) in mice: involvement of dopaminergic system

Francisca Helvira Cavalcante Melo, Brinell Arcanjo Moura, Damião Pergentino de Sousa, Silvânia Maria Mendes de Vasconcelos, more

Fundamental & Clinical Pharmacology > 25 > 3 > 362 - 367

Carvacrol (5‐isopropyl‐2‐methylphenol) is a monoterpenic phenol present in the essential oil of many plants. It is the major component of the essential oil fraction of oregano and thyme. In this study, the effect of carvacrol was investigated in two behavioral models, the forced swimming and tail suspension tests in mice, to investigate the possible antidepressant effect of this substance. Additionally,...

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Mechanisms involved in the gastroprotective activity of esculin on acute gastric lesions in mice

Emiliano Ricardo Vasconcelos Rios, Nayrton Flávio Moura Rocha, Edith Teles Venâncio, Brinell Arcanjo Moura, more

Chemico-Biological Interactions > 2010 > 188 > 1 > 246-254

This work describes the gastroprotective actions of esculin (6,7-dihydroxycoumarin-6-o-glucoside) against indomethacin- or ethanol-induced lesions and verifies the role of nitric oxide, ATP-dependent K ⁺ channels, prostaglandins, transient receptor potential vanilloid 1 and antioxidant effects in the gastroprotective mechanism of esculin in the ethanol-induced gastric lesion model. The intragastric...

article

Anxiolytic-like effect of the monoterpene 1,4-cineole in mice

Patrícia Bezerra Gomes, Mariana Lima Feitosa, Maria Izabel Gomes Silva, Emmanuelle Coelho Noronha, more

Pharmacology, Biochemistry and Behavior > 2010 > 96 > 3 > 287-293

Recent studies have shown that some monoterpenes exert anxiolytic- and depressant-like actions, however, these effects from monoterpene 1,4-cineole are still unknown. This work aimed to study the effects of 1,4-cineole in classic animal models for depression- and anxiety-like behavior, specifically the elevated plus maze (EPM), hole board, open field, pentobarbital sleeping time, forced swimming,...

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Behavioral alterations and pro-oxidant effect of a single ketamine administration to mice

Francisca Charliane Carlos da Silva, Maria do Carmo de Oliveira Cito, Maria Izabel Gomes da Silva, Brinell Arcanjo Moura, more

Brain Research Bulletin > 2010 > 83 > 1-2 > 9-15

A growing body of evidence has pointed to the ionotropic glutamate N-methyl-d-aspartate receptor (NMDA) as an important player in the etiology of psychopathologies, including anxiety and major depression. Clinical findings suggest that ketamine may be used for the treatment of major depression. There is evidence that reactive oxygen species also play an important role in the pathogenesis of many diseases,...

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Gastroprotection of (‐)‐α‐bisabolol on acute gastric mucosal lesions in mice: the possible involved pharmacological mechanisms

Nayrton Flávio Moura Rocha, Edith Teles Venâncio, Brinell Arcanjo Moura, Maria Izabel Gomes Silva, more

Fundamental & Clinical Pharmacology > 24 > 1 > 63 - 71

(‐)‐α‐Bisabolol is an unsaturated, optically active sesquiterpene alcohol obtained by the direct distillation essential oil from plants such as Vanillosmopsis erythropappa and Matricaria chamomilla. (‐)‐α‐Bisabolol has generated considerable economic interest, since it possesses a delicate floral odor and has been shown to have anti‐septic and anti‐inflammatory activity. The aim of this work was to...

article

Effects of isopulegol on pentylenetetrazol-induced convulsions in mice: Possible involvement of GABAergic system and antioxidant activity

Maria Izabel Gomes Silva, Maria Angélica Gomes Silva, Manuel Rufino de Aquino Neto, Brinell Arcanjo Moura, more

Fitoterapia > 2009 > 80 > 8 > 506-513

The present study investigated the effects of isopulegol, a monoterpene alcohol, in PTZ-induced convulsions and verified possible involved mechanisms. Saline, isopulegol or diazepam were intraperitonealy injected 30min before PTZ. The latency for development of convulsions and mortality, as well as the mortality protection percentage was recorded. For investigating the involvement of GABAergic system,...

article

Gastroprotective activity of isopulegol on experimentally induced gastric lesions in mice: investigation of possible mechanisms of action

Maria Izabel Gomes Silva, Brinell Arcanjo Moura, Manuel Rufino Aquino Neto, Adriana Rocha Tomé, more

Naunyn-Schmiedeberg's Archives of Pharmacology > 2009 > 380 > 3 > 233-245

The present study investigated whether isopulegol, a monoterpene present in essential oils of several aromatic plants, would be able to promote some gastroprotective effect and also verified the possible mechanisms involved in this action. For this study, ethanol- and indomethacin-induced gastric ulcer models in mice and histopathological assessment were used. The roles of NO, sulfhydryls (glutathione,...

article

Central nervous system activity of acute administration of isopulegol in mice

Maria Izabel Gomes Silva, Manuel Rufino de Aquino Neto, Paulo Florentino Teixeira Neto, Brinell Arcanjo Moura, more

Pharmacology, Biochemistry and Behavior > 2007 > 88 > 2 > 141-147

Isopulegol is a monoterpene alcohol intermediate in the preparation of (−)-menthol and it is present in the essential oils of various plants. This work presents behavioral effects of isopulegol in animal models of open field, elevated plus maze (EPM), rota rod, hole board, barbiturate-induced sleeping time, tail suspension and forced swimming tests in mice. Isopulegol was administered intraperitoneally...

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