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N‐glycosylation is a common post‐translational modification of G‐protein‐coupled receptors (GPCRs). However, it remains unknown how N‐glycosylation affects GPCR signaling. β2 adrenergic receptor (β2AR) has three N‐glycosylation sites: Asn6, Asn15 at the N‐terminus, and Asn187 at the second extracellular loop (ECL2). Here, we show that deletion of the N‐glycan did not affect receptor expression and...
Chemoenzymatic glycoengineering of immunoglobulin G (IgG) catalyzed by Endo-S is a powerful approach to remodel the heterogeneous N-glycoforms of Fc domain with a homogeneous synthetic glycan structure for enhanced Fc receptor-mediated effector functions. The previous researches on the method development mainly focused on human or humanized IgGs with therapeutic potentials. Here, for the first time...
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