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Sepsis is a significant cause of hospital deaths, but early detection could save lives. Heart rate variability (HRV) is a measurement of the change in heart rate and may be useful as a marker for early detection of sepsis. In this study, E. coli endotoxin was administered to healthy human subjects and changes in temperature and HRV were monitored at 6 hours post administration. HRV features measured...
Septic shock is a leading cause of hospital deaths in the United States. A system to detect initial immune response to an infection could allow for treatment before septic shock occurs, which would save many lives. Here, we demonstrate the analysis of beat-to-beat heart rate intervals using the Hilbert-Huang transform (HHT) as a method of detection of the immune/inflammatory response. The HHT is ideal...
The Mdm2-SNP309(T/G) polymorphism has been shown to upregulate transcription of Mdm2 and subsequently attenuate the p53 pathway. Its role in regulating the human response to acute illness has not been reported.Patients from the surgical intensive care unit were prospectively enrolled. SNP309 genotype was determined, and a genotype-based comparison of clinical outcomes was performed.Of the 85 enrolled...
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