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Cholinergic basal forebrain (CBF) projection systems are defective in late Alzheimer's disease (AD). We examined the brains of 12-month-old singly and doubly transgenic mice overexpressing mutant amyloid precursor protein (APP swe ) and/or presenilin-1 (PS1 M146L ) to investigate the effects of these AD-related genes on plaque and tangle pathology, astrocytic expression, and the CBF...