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Cholinergic basal forebrain (CBF) projection systems are defective in late Alzheimer's disease (AD). We examined the brains of 12-month-old singly and doubly transgenic mice overexpressing mutant amyloid precursor protein (APP swe ) and/or presenilin-1 (PS1 M146L ) to investigate the effects of these AD-related genes on plaque and tangle pathology, astrocytic expression, and the CBF...
Lentiviral vectors infect quiescent cells and allow for the delivery of genes to discrete brain regions. The present study assessed whether stable lentiviral gene transduction can be achieved in the monkey nigrostriatal system. Three young adult Rhesus monkeys received injections of a lentiviral vector encoding for the marker gene β galatosidase (βGal). On one side of the brain, each monkey received...
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