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The VR1012NH36 DNA vaccine was immunoprophylactic and immunotherapeutic against mice visceral leishmaniasis by L.(L.) chagasi and cutaneous leishmaniasis by L. (L.) mexicana. We here evaluated the protection induced by three sc doses of FML (150μg) + saponin (100μg), or two doses of VR1012 empty plasmid (100μg) or VR1012NH36 (100μg) vaccine against the footpad L. (L.) amazonensis infection with 1...
A group of 600 healthy and asymptomatic dogs from Brazilian canine visceral leishmaniasis endemic areas was vaccinated with three sc doses of Leishmune ® which is the industrialized formulation of the FML-saponin, recently licensed for commercialization in Brazil, which previously showed 76–80% vaccine efficacy against canine visceral leishmaniasis. Safety evaluation was performed for 14 days...
The adjuvant of the FML-vaccine against murine and canine visceral leishmaniasis, the Riedel de Haen saponin mixture, was fractionated by ion exchange chromatography on DEAE-cellulose to afford one TLC homogeneous Quillaja saponaria Molina QS21 saponin fraction (18.0%), a mixture of two deacylsaponins (19.4%), sucrose (39.9%), sucrose and glucose (19.7%), rutin (0.8%) and quercetin (2.2%), that were...
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