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Leishmune ® is the industrialized version of the FML-saponin vaccine which has been shown to develop 92–95% protection in vaccinated dogs and 76–80% vaccine efficacy against field canine visceral leishmaniasis (CVL) in Brazil. Leishmune ® has been proven to be safe and tolerable and a transmission-blocking vaccine which renders vaccinated dogs non-infectious to sand fly vectors. In...
The objective of the present experiments was to study the effects of pulmonary inflammation induced by subacute Sulfur-dioxide (SO 2 ) exposure on capsaicin-induced responses in isolated primary vagal sensory neurons and cough. Additionally, we examined the effects of SO 2 exposure on respiratory function and lung histology. All experiments were conducted 24h after 4 days of subacute...
A group of 600 healthy and asymptomatic dogs from Brazilian canine visceral leishmaniasis endemic areas was vaccinated with three sc doses of Leishmune ® which is the industrialized formulation of the FML-saponin, recently licensed for commercialization in Brazil, which previously showed 76–80% vaccine efficacy against canine visceral leishmaniasis. Safety evaluation was performed for 14 days...
Leishmune ® vaccine is the first licensed vaccine against canine visceral leishmaniasis. It contains the Fucose–Mannose-ligand (FML) antigen of Leishmania donovani. The potential Leishmune ® vaccine effect on the interruption of the transmission of the disease, was assayed by monitoring, in untreated (n=40) and vaccinated dogs (n=32) of a Brazilian epidemic area: the kala-azar clinical...
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