Search results for: Norihiro Watanabe

Items from 1 to 20 out of 30 results

article

Expanding CAR T cells in human platelet lysate renders T cells with in vivo longevity

Alejandro Torres Chavez, Mary Kathryn McKenna, Emanuele Canestrari, Christina T. Dann, more

Journal for ImmunoTherapy of Cancer > 2019 > 7 > 1 > 1-15

Background Pre-clinical and clinical studies have shown that the infusion of CAR T cells with a naive-like (T_N) and central memory (T_CM) phenotype is associated with prolonged in vivo T cell persistence and superior anti-tumor effects. To optimize the maintenance of such populations during the in vitro preparation process, we explored the impact of T cell exposure to both traditional [fetal bovine...

article

CAR T cell therapy for breast cancer: harnessing the tumor milieu to drive T cell activation

Pradip Bajgain, Supannikar Tawinwung, Lindsey D’Elia, Sujita Sukumaran, more

Journal for ImmunoTherapy of Cancer > 2018 > 6 > 1 > 1-13

Background The adoptive transfer of T cells redirected to tumor via chimeric antigen receptors (CARs) has produced clinical benefits for the treatment of hematologic diseases. To extend this approach to breast cancer, we generated CAR T cells directed against mucin1 (MUC1), an aberrantly glycosylated neoantigen that is overexpressed by malignant cells and whose expression has been correlated with...

article

Thermal convection of viscous fluids in a faulted system: 3D benchmark for numerical codes

Fabien Magri, Mauro Cacace, Thomas Fischer, Olaf Kolditz, more

Energy Procedia > 2017 > 125 > C > 310-317

We propose a new benchmark for the simulation of thermal convection in a 3D faulted system. Linear stability analysis is adopted to estimate the critical viscous-dependent Rayleigh number. These results are used to quantify the reliability of OpenGeoSys-5, Golem and FEFLOW simulators in accounting for the onset conditions and in predicting the long-term behavior of convective flow patterns. By comparing...

article

Calibration of water–granite interaction with pressure solution in a flow-through fracture under confining pressure

Renchao Lu, Norihiro Watanabe, Wenkui He, Eunseon Jang, more

Environmental Earth Sciences > 2017 > 76 > 12 > 1-14

Fluid–mineral interaction has an irreversible impact on the fracture permeability evolution in the life span of deep geological reservoirs. To investigate the impact, a preliminary study on water–granite interaction in an undeformable fracture under confining pressure is conducted. A 1-D flow and reactive transport model is therefore developed and validated against the experimental data in Yasuhara...

chapter

A study on the effect of the stator tooth width on the characteristics of three-phase squirrel-cage induction motor with six stator slots

Norihiro Watanabe, Masanori Nakamura, Isao Hirotsuka, Yuta Funaki

2016 19th International Conference on Electrical Machines and Systems (ICEMS) > 1 - 6

2016 19th International Conference on Electrical Machines and Systems (ICEMS)

In recent years, the motive power of industrial machines has increased, and induction motors are now being used many applications. Consequently, there is increasing demand to reduce the cost of these motors. One method that can be used to lower the cost is to change the stator winding structures to use concentrated windings. However, induction motors with concentrated windings have not been studied...

article

Thermo-poroelastic numerical modelling for enhanced geothermal system performance: Case study of the Groß Schönebeck reservoir

Antoine B. Jacquey, Mauro Cacace, Guido Blöcher, Norihiro Watanabe, more

Tectonophysics > 2016 > 684 > C > 119-130

Significant pressure and temperature changes can occur within geothermal reservoirs caused by injection and production of fluid which can affect transport properties of the rocks and therefore alter reservoir performance and sustainability. To understand the coupling between transport properties evolution and state variable changes, a complete description of the mechanical behavior of the reservoir...

article

PWM Carrier Harmonic Iron Loss Reduction Technique of Permanent-Magnet Motors for Electric Vehicles

Yoshihiro Miyama, Moriyuki Hazeyama, Shota Hanioka, Norihiro Watanabe, more

IEEE Transactions on Industry Applications > 2016 > 52 > 4 > 2865 - 2871

This paper investigates a method to increase fuel economy of motors for an electric vehicle (EV) traction system. The low-torque region of an EV motor is frequently used in everyday urban driving and in fuel economy measurement. Pulsewidth modulation (PWM) carrier harmonic iron loss accounts for a high percentage of total loss for EV motors in this region. This paper reveals the relationship between...

article

Go-Rex: A Novel in Vitro System for the Assessment of CAR T Cell Function

Pradip Bajgain, Usanarat Anurathapan, Ayumi Watanabe, John Wilson, more

Biology of Blood and Marrow Transplantation > 2016 > 22 > 3(S) > S425

chapter

A study of the effect of the stator tooth shape on the characteristics of three-phase induction motor with concentrated windings

Yuta Funaki, Norihiro Watanabe, Masanori Nakamura, Isao Hirotsuka, more

2015 18th International Conference on Electrical Machines and Systems (ICEMS) > 150 - 155

2015 18th International Conference on Electrical Machines and Systems (ICEMS)

As the prime mover of industrial machines, the three-phase squirrel-cage induction motor (IM) has been typically used. Consequently, further price reduction has been required. Although the price has decreased on account of its change from distributed winding to concentric winding, IM with concentric winding has not been adequately studied. Therefore, in this study, we have examined the potential of...

article

Evaluation of three exploitation concepts for a deep geothermal system in the North German Basin

Guido Blöcher, Mauro Cacace, Thomas Reinsch, Norihiro Watanabe

Computers and Geosciences > 2015 > 82 > Complete > 120-129

In this paper, we compare three exploitation strategies for the deep geothermal system of Groß Schönebeck in the North German Basin. Investigating optimum reservoir designs is one of the key issues for efficient and sustainable utilization of geothermal resource. With this objective we simulate the hydraulic-thermal coupled subsurface processes related to the provision of geothermal energy. The presented...

chapter

PWM carrier harmonic iron loss reduction technique of permanent magnet motors for electric vehicles

Yoshihiro Miyama, Moriyuki Hazeyama, Shota Hanioka, Norihiro Watanabe, more

2015 IEEE International Electric Machines & Drives Conference (IEMDC) > 475 - 481

2015 IEEE International Electric Machines & Drives Conference (IEMDC)

This paper is investigated to increase fuel economy of motor for electric vehicles (EVs) traction system. Low torque region of EV motor is frequently-used point in usual urban driving and in fuel economy measurement. Pulse-width modulation (PWM) carrier harmonic iron loss takes up high percentage for EV motors in this region. This paper reveals the relationship between phase current and carrier harmonic...

article

Go-CART: an animal-free system for the assessment of CAR T cell function

Pradip Bajgain, Usanarat Anurathapan, Ayumi Watanabe, John Wilson, more

Journal for ImmunoTherapy of Cancer > 2015 > 3 > 2 > 1-2

article

Hydro-Mechanical Evolution of Transport Properties in Porous Media: Constraints for Numerical Simulations

Antoine B. Jacquey, Mauro Cacace, Guido Blöcher, Norihiro Watanabe, more

Transport in Porous Media > 2015 > 110 > 3 > 409-428

During geothermal operations, injection and production of fluid can induce significant pore pressure and temperature changes which impact the stress field thus affecting the reservoir performance. In this context, the transport and mechanical properties of the porous rock can be altered by deformation of the pore and bulk volumes. Different poroelastic formulations for describing the hydro-mechanical...

article

Screening of a heptamer-type sgRNA library for potential therapeutic agents against hematological malignancies

Masayuki Takahashi, Reyad A. Elbarbary, Norihiro Watanabe, Atsushi Goto, more

Leukemia Research > 2014 > 38 > 7 > 808-815

tRNase-Z ^L -utilizing efficacious (TRUE) gene silencing is an RNA-mediated gene expression control technology that has therapeutic potential. This technology is based on the property of tRNase Z ^L that it can cleave any target RNA at any desired site under the direction of an appropriate artificial small guide RNA (sgRNA). To search for novel potential therapeutic sgRNAs for hematological...

article

OpenGeoSys-Gem: A numerical tool for calculating geochemical and porosity changes in saturated and partially saturated media

Georg Kosakowski, Norihiro Watanabe

Physics and Chemistry of the Earth > 2014 > 70-71 > Complete > 138-149

Reactive transport codes that use a Gibbs Energy Minimization (GEM) to solve chemical equilibria are uncommon. We present a new coupling of the Richards flow module of the Finite Element (FE) based OpenGeoSys code with the GEM based chemical solver GEMS3K. The coupled code is highly parallelized using an overlapping domain decomposition approach in combination with execution of multiple threads that...

article

TESSIN VISLab—laboratory for scientific visualization

Lars Bilke, Thomas Fischer, Carolin Helbig, Charlotte Krawczyk, more

Environmental Earth Sciences > 2014 > 72 > 10 > 3881-3899

Scientific visualization is an integral part of the modeling workflow, enabling researchers to understand complex or large data sets and simulation results. A high-resolution stereoscopic virtual reality (VR) environment further enhances the possibilities of visualization. Such an environment also allows collaboration in work groups including people of different backgrounds and to present results...

article

Induction of apoptosis of leukemic cells by TRUE gene silencing using small guide RNAs targeting the WT1 mRNA

Norihiro Watanabe, Miwako Narita, Akie Yamahira, Tomoyo Taniguchi, more

Leukemia Research > 2013 > 37 > 5 > 580-585

TRUE gene silencing is a technology to eliminate specific cellular RNAs by using tRNase Z ^L and small guide RNA (sgRNA). Here we investigated how WT1-mRNA-targeting sgRNAs affect leukemic cells. We showed that sgRNA can be easily taken up by cells without any transfection reagents, and that the naked sgRNAs targeting the WT1 mRNA can reduce its mRNA levels and WT1 protein amounts in the WT1-expressing...

article

Modelling of fractured carbonate reservoirs: outline of a novel technique via a case study from the Molasse Basin, southern Bavaria, Germany

Mauro Cacace, Guido Blöcher, Norihiro Watanabe, Inga Moeck, more

Environmental Earth Sciences > 2013 > 70 > 8 > 3585-3602

Fluid flow in low-permeable carbonate rocks depends on the density of fractures, their interconnectivity and on the formation of fault damage zones. The present-day stress field influences the aperture hence the transmissivity of fractures whereas paleostress fields are responsible for the formation of faults and fractures. In low-permeable reservoir rocks, fault zones belong to the major targets...

article

A naked RNA heptamer targeting the human Bcl-2 mRNA induces apoptosis of HL60 leukemia cells

Masayuki Takahashi, Reyad A. Elbarbary, Aiko Nakashima, Mayumi Abe, more

Cancer Letters > 2013 > 328 > 2 > 362-368

tRNase Z ^L -utilizing efficacious gene silencing is a gene control technology, which is based on the property that tRNase Z ^L can cleave any target RNA under the direction of an appropriate small guide RNA (sgRNA). To find therapeutic sgRNAs to cure hematological malignancies, we investigated behavior of heptamer-type sgRNA. We demonstrated that a heptamer, mh1(Bcl-2), which targets...

article

3D Hydro-mechanical Scenario Analysis to Evaluate Changes of the Recent Stress Field as a Result of Geological CO2 Storage

Fabien Magri, Elena Tillner, Wenquing Wang, Norihiro Watanabe, more

Energy Procedia > 2013 > 40 > Complete > 375-383

A numerical scheme coupling TOUGH2 and the hydro-mechanical simulator OpenGeoSys is used to evaluate the deformations and in situ stress changes induced by CO ₂ injection at a potential storage site located in the Northeast German Basin (NEGB). Scenario analysis shows that under the given assumptions the vertical displacement of the reservoir is negligible and significant changes in the recent...

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INFONA - science communication portal

Search results for: Norihiro Watanabe

Expanding CAR T cells in human platelet lysate renders T cells with in vivo longevity

CAR T cell therapy for breast cancer: harnessing the tumor milieu to drive T cell activation

Thermal convection of viscous fluids in a faulted system: 3D benchmark for numerical codes

Calibration of water–granite interaction with pressure solution in a flow-through fracture under confining pressure

A study on the effect of the stator tooth width on the characteristics of three-phase squirrel-cage induction motor with six stator slots

Thermo-poroelastic numerical modelling for enhanced geothermal system performance: Case study of the Groß Schönebeck reservoir

PWM Carrier Harmonic Iron Loss Reduction Technique of Permanent-Magnet Motors for Electric Vehicles

Go-Rex: A Novel in Vitro System for the Assessment of CAR T Cell Function

A study of the effect of the stator tooth shape on the characteristics of three-phase induction motor with concentrated windings

Evaluation of three exploitation concepts for a deep geothermal system in the North German Basin

PWM carrier harmonic iron loss reduction technique of permanent magnet motors for electric vehicles

Go-CART: an animal-free system for the assessment of CAR T cell function

Hydro-Mechanical Evolution of Transport Properties in Porous Media: Constraints for Numerical Simulations

Screening of a heptamer-type sgRNA library for potential therapeutic agents against hematological malignancies

OpenGeoSys-Gem: A numerical tool for calculating geochemical and porosity changes in saturated and partially saturated media

TESSIN VISLab—laboratory for scientific visualization

Induction of apoptosis of leukemic cells by TRUE gene silencing using small guide RNAs targeting the WT1 mRNA

Modelling of fractured carbonate reservoirs: outline of a novel technique via a case study from the Molasse Basin, southern Bavaria, Germany

A naked RNA heptamer targeting the human Bcl-2 mRNA induces apoptosis of HL60 leukemia cells

3D Hydro-mechanical Scenario Analysis to Evaluate Changes of the Recent Stress Field as a Result of Geological CO2 Storage

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