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Although the co‐stimulatory interaction between B and T cells is well defined, recent evidence suggests that B cells also have a regulatory role. Here, we show that B cells activated using anti‐IgD conjugated to dextran (α‐δ‐dex) directly inhibit T‐cell receptor‐induced CD4 T‐cell activation, proliferation and cytokine production. This effect was observed in CD4 T cells activated both with and without...
Meningococcal septicaemia is characterised by high bacterial titres in blood and an increased production of circulating nitric oxide metabolites, including nitrates NO3-, nitrites NO2- and S-nitrosothiol [SNO]. The formation of SNO, termed S-nitrosylation, is an important form of post-translational protein modification akin to phosphorylation. Previously, bacterial NO detoxification was demonstrated...
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