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Meningococcal septicaemia is characterised by high bacterial titres in blood and an increased production of circulating nitric oxide metabolites, including nitrates NO3-, nitrites NO2- and S-nitrosothiol [SNO]. The formation of SNO, termed S-nitrosylation, is an important form of post-translational protein modification akin to phosphorylation. Previously, bacterial NO detoxification was demonstrated...
Increased bacterial load in meningococcal sepsis is positively correlated with severe disease and increased concentrations of circulating nitric oxide (NO) metabolites. As a vasorelaxant, NO binds to the soluble guanylyl cyclase (sGC), found in abundance in vascular smooth muscle and activates cGMP, a secondary messenger important for vasodilation, platelet inhibition etc. We previously showed that...