Search results for: Kyung Min Chung

Items from 1 to 20 out of 21 results

article

Cross‐protection against Vibrio cholerae infection by monoclonal antibodies against Vibrio vulnificus RtxA1/MARTX_Vv

Tae Hee Lee, Sun‐Shin Cha, Chang‐Seop Lee, Joon Haeng Rhee, more

Microbiology and Immunology > 60 > 11 > 793 - 800

Gram‐negative Vibrio species secrete multifunctional autoprocessing repeats‐in‐toxin (MARTX) toxins associated with bacterial pathogenesis. Here, the cross‐reactivity and cross‐protectivity of mAbs against V. vulnificus RtxA1/MARTX_Vv was evaluated. Passive administration of any of these mAbs (21RA, 24RA, 46RA, 47RA and 50RA) provided strong protection against lethal V. cholerae infection. Interestingly,...

article

Valosin-containing protein is a key mediator between autophagic cell death and apoptosis in adult hippocampal neural stem cells following insulin withdrawal

Bo Kyoung Yeo, Caroline Jeeyeon Hong, Kyung Min Chung, Hanwoong Woo, more

Molecular Brain > 2016 > 9 > 1 > 1-14

Background Programmed cell death (PCD) plays essential roles in the regulation of survival and function of neural stem cells (NSCs). Abnormal regulation of this process is associated with developmental and degenerative neuronal disorders. However, the mechanisms underlying the PCD of NSCs remain largely unknown. Understanding the mechanisms of PCD in NSCs is crucial for exploring therapeutic strategies...

article

Development and characterization of a catalytically inactive cysteine protease domain of RtxA1/MARTX_Vv as a potential vaccine for Vibrio vulnificus

Tae Hee Lee, Kyung Min Chung

Microbiology and Immunology > 59 > 9 > 555 - 561

Recent studies have defined several virulence factors as vaccine candidates against Vibrio vulnificus. However, most of these factors have the potential to cause pathogenic effects in the vaccinees or induce incomplete protection. To overcome these drawbacks, a catalytically inactive form, CPD_Vv(C3725S), of the well‐conserved cysteine protease domain (CPD) of V. vulnificus multifunctional autoprocessing...

article

Regulation of autophagic cell death by glycogen synthase kinase-3β in adult hippocampal neural stem cells following insulin withdrawal

Shinwon Ha, Hye Young Ryu, Kyung Min Chung, Seung-Hoon Baek, more

Molecular Brain > 2015 > 8 > 1 > 1-12

Background Neural stem cells (NSCs) hold great potential for the treatment of neurodegenerative diseases. However, programmed cell death (PCD) provoked by the harsh conditions evident in the diseased brain greatly undermines the potential of NSCs. Currently, the mechanisms of PCD that effect NSCs remain largely unknown. Results We have previously reported that hippocampal neural stem (HCN) cells...

article

Cytokine and endocrine parameters in mouse chronic social defeat: Implications for translational ‘cross-domain’ modeling of stress-related brain disorders

Adam Michael Stewart, Sudipta Roy, Keith Wong, Siddharth Gaikwad, more

Behavioural Brain Research > 2015 > 276 > C > 84-91

Mounting clinical and experimental evidence implicates various cytokines in stress-related affective brain disorders. Here, we analyze behavioral phenotypes in C57BL/6J male mice following the chronic social defeat stress paradigm, and examine their serum cytokines and corticosterone levels. Loser mice experiencing 20 days of daily 15-min social confrontations demonstrate elevated levels of pro-inflammatory...

article

Arabidopsis VIM Proteins Regulate Epigenetic Silencing by Modulating DNA Methylation and Histone Modification in Cooperation with MET1

Jeongsik Kim, Jin Hee Kim, Eric J. Richards, Kyung Min Chung, more

Molecular Plant > 2014 > 7 > 9 > 1470-1485

Methylcytosine-binding proteins containing SRA (SET- and RING-Associated) domain are required for the establishment and/or maintenance of DNA methylation in both plants and animals. We previously proposed that Arabidopsis VIM/ORTH proteins with an SRA domain maintain DNA methylation and epigenetic gene silencing in heterochromatic regions. However, their endogenous targets of epigenetic gene silencing...

article

ATP-binding mode including a carbamoylated lysine and two Mg2+ ions, and substrate-binding mode in Acinetobacter baumannii MurF

Sun-Shin Cha, Young Jun An, Chang-Sook Jeong, Jeong Hee Yu, more

Biochemical and Biophysical Research Communications > 2014 > 450 > 2 > 1045-1050

MurF adds d-Ala-d-Ala dipeptide to UDP-N-acetylmuramyl-l-Ala-γ-d-Glu-m-DAP (or l-Lys) in an ATP-dependent manner, which is the last step in the biosynthesis of monomeric precursor of peptidoglycan. Here we report crystal structures of two MurF–ATP complexes: the MurF–ATP complex and the MurF–ATP–UDP complex. The ATP-binding mode revealed by the crystal structure of the MurF–ATP complex confirms the...

article

Purification, crystallization and preliminary X‐ray crystallographic analysis of the UDP‐N‐acetylmuramoyl‐tripeptide‐D‐alanyl‐D‐alanine ligase (MurF) from Acinetobacter baumannii

Young Jun An, Chang‐Sook Jeong, Jeong Hee Yu, Kyung Min Chung, more

Acta Crystallographica Section F > 70 > 7 > 976 - 978

The emergence and global spread of multidrug‐resistant Acinetobacter baumannii strains are major threats to public health. Inhibition of peptidoglycan biosynthesis is an effective strategy for the development of antibiotics. The ATP‐dependent UDP‐N‐acetylmuramoyl‐tripeptide‐D‐alanyl‐D‐alanine ligase (MurF) that is responsible for the last step of peptidoglycan biosynthesis is a validated target for...

article

Expression, crystallization and preliminary X‐ray crystallographic analysis of D‐alanine‐D‐alanine ligase from OXA‐23‐producing Acinetobacter baumannii K0420859

Kim‐Hung Huynh, Huyen‐Thi Tran, Tan‐Viet Pham, Ho‐Phuong‐Thuy Ngo, more

Acta Crystallographica Section F > 70 > 4 > 505 - 508

Acinetobacter baumannii causes bacteraemia, pneumonia, other respiratory‐tract and urinary‐tract infections in humans. OXA‐23 carbapenemase‐producing A. baumannii K0420859 (A. baumannii OXA‐23) is resistant to carbapenem, a common antibacterial drug. To develop an efficient and novel antibacterial drug against A. baumannii OXA‐23, D‐alanine‐D‐alanine ligase, which is essential in bacterial cell‐wall...

article

Crystal structures of d-alanine-d-alanine ligase from Xanthomonas oryzae pv. oryzae alone and in complex with nucleotides

Thanh Thi Ngoc Doan, Jin-Kwang Kim, Ho-Phuong-Thuy Ngo, Huyen-Thi Tran, more

Archives of Biochemistry and Biophysics > 2014 > 545 > Complete > 92-99

d-Alanine-d-alanine ligase (DDL) catalyzes the biosynthesis of d-alanyl-d-alanine, an essential bacterial peptidoglycan precursor, and is an important drug target for the development of antibacterials. We determined four different crystal structures of DDL from Xanthomonas oryzae pv. oryzae (Xoo) causing Bacteria Blight (BB), which include apo, ADP-bound, ATP-bound, and AMPPNP-bound structures at...

article

Protection against Vibrio vulnificus infection by active and passive immunization with the C-terminal region of the RtxA1/MARTXVv protein

Tae Hee Lee, Mi Hyun Kim, Chang-Seop Lee, Ju-Hyung Lee, more

Vaccine > 2014 > 32 > 2 > 271-276

Vibrio vulnificus is a foodborne pathogen that is prevalent in coastal waters worldwide. Infection with V. vulnificus causes septicemia with fatality rates exceeding 50% even with aggressive antibiotic therapy. Several vaccine studies to prevent V. vulnificus infection have been performed but have had limited success. In this study, we identified the C-terminal region (amino acids 3491 to 4701) of...

article

Overexpression of AtCHX24, a member of the cation/H+ exchangers, accelerates leaf senescence in Arabidopsis thaliana

Yoonkang Hur, Jin Hee Kim, Dong-Joon Lee, Kyung Min Chung, more

Plant Science > 2012 > 183 > Complete > 175-182

Leaf senescence, the final stage of leaf development, occurs in an age-dependent manner but can be finely regulated by other developmental and environmental factors. Despite the discovery of many genes involved in leaf senescence, the molecular genetic mechanisms of leaf senescence are still unclear. In this study, an activation-tagging based suppressor screen was performed to identify Arabidopsis...

article

Characterization of monoclonal antibodies targeting the RtxA1 toxin of Vibrio vulnificus

Tae Hee Lee, Young Ran Kim, Joon Haeng Rhee, Jin-Hong Kim, more

Process Biochemistry > 2011 > 46 > 7 > 1500-1508

Vibrio vulnificus is a lethal pathogen that is responsible for most seafood-related deaths. The mortality rate for susceptible individuals is higher than 50% within 1–2days after contact with the bacteria. Recent studies suggest that RtxA1, a secreted bacterial toxin, plays a key role in the cytotoxicity and pathogenesis of V. vulnificus. Despite the important role of RtxA1 in the virulence of V....

article

Three positive regulators of leaf senescence in Arabidopsis, ORE1, ORE3 and ORE9, play roles in crosstalk among multiple hormone-mediated senescence pathways

Jin Hee Kim, Kyung Min Chung, Hye Ryun Woo

Genes & Genomics > 2011 > 33 > 4 > 373-381

Leaf senescence is a developmentally programmed event, but the initiation and progression of leaf senescence are affected by a range of plant hormones including abscisic acid (ABA), ethylene and methyl jasmonate (MeJA). To investigate plant hormone crosstalk during leaf senescence, hormone-induced senescence phenotypes were analyzed in three leaf senescence mutants [ore1 (oresara1), ore3 and ore9]...

article

Characterization of behavioral and endocrine effects of LSD on zebrafish

Leah Grossman, Eli Utterback, Adam Stewart, Siddharth Gaikwad, more

Behavioural Brain Research > 2010 > 214 > 2 > 277-284

Lysergic acid diethylamide (LSD) is a potent hallucinogenic drug that strongly affects animal and human behavior. Although adult zebrafish (Danio rerio) are emerging as a promising neurobehavioral model, the effects of LSD on zebrafish have not been investigated previously. Several behavioral paradigms (the novel tank, observation cylinder, light–dark box, open field, T-maze, social preference and...

article

Analyzing habituation responses to novelty in zebrafish (Danio rerio)

Keith Wong, Marco Elegante, Brett Bartels, Salem Elkhayat, more

Behavioural Brain Research > 2010 > 208 > 2 > 450-457

Analysis of habituation is widely used to characterize animal cognitive phenotypes and their modulation. Although zebrafish (Danio rerio) are increasingly utilized in neurobehavioral research, their habituation responses have not been extensively investigated. Utilizing the novel tank test, we examine intra- and inter-session habituation and demonstrate robust habituation responses in adult zebrafish...

article

The effects of chronic social defeat stress on mouse self-grooming behavior and its patterning

Ashley Denmark, David Tien, Keith Wong, Amanda Chung, more

Behavioural Brain Research > 2010 > 208 > 2 > 553-559

Stress induced by social defeat is a strong modifier of animal anxiety and depression-like phenotypes. Self-grooming is a common rodent behavior, and has an ordered cephalo-caudal progression from licking of the paws to head, body, genitals and tail. Acute stress is known to alter grooming activity levels and disrupt its patterning. Following 15–17 days of chronic social defeat stress, grooming behavior...

article

Modeling withdrawal syndrome in zebrafish

Jonathan Cachat, Peter Canavello, Marco Elegante, Brett Bartels, more

Behavioural Brain Research > 2010 > 208 > 2 > 371-376

The zebrafish (Danio rerio) is rapidly becoming a popular model species in behavioral neuroscience research. Zebrafish behavior is robustly affected by environmental and pharmacological manipulations, and can be examined using exploration-based paradigms, paralleled by analysis of endocrine (cortisol) stress responses. Discontinuation of various psychotropic drugs evokes withdrawal in both humans...

article

Development and characterization of non-glycosylated E and NS1 mutant viruses as a potential candidate vaccine for West Nile virus

Melissa C. Whiteman, Li Li, Jason A. Wicker, Richard M. Kinney, more

Vaccine > 2010 > 28 > 4 > 1075-1083

West Nile virus is an arthropod-borne flavivirus that has caused substantial morbidity and mortality to animals as well as humans since its introduction in to the New York area in 1999. Given that there are no antiviral drugs available for treatment of the disease, vaccines provide an efficacious alternative to control this disease. Herein we describe an attenuated WNV strain developed by the ablation...

article

Downregulation of Wnt-Mediated ROS generation is causally implicated in leprechaunism

Ji Won Park, Hye Sun Kuehn, So Youn Kim, Kyung Min Chung, more

Molecules and Cells > 2010 > 29 > 1 > 63-69

Although mutations in the insulin receptor have been causally implicated with leprechaunsim, the full pathophysiology of the syndrome cannot be accounted for by malfunction of this gene alone. We sought to characterize a connection between Wnt-mediated cell signaling and the production of reactive oxygen species (ROS) which revealed a novel mechanistic basis for understanding the pathogenesis of leprechaunism...

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Search results for: Kyung Min Chung

Cross‐protection against Vibrio cholerae infection by monoclonal antibodies against Vibrio vulnificus RtxA1/MARTX_Vv

Valosin-containing protein is a key mediator between autophagic cell death and apoptosis in adult hippocampal neural stem cells following insulin withdrawal

Development and characterization of a catalytically inactive cysteine protease domain of RtxA1/MARTX_Vv as a potential vaccine for Vibrio vulnificus

Regulation of autophagic cell death by glycogen synthase kinase-3β in adult hippocampal neural stem cells following insulin withdrawal

Cytokine and endocrine parameters in mouse chronic social defeat: Implications for translational ‘cross-domain’ modeling of stress-related brain disorders

Arabidopsis VIM Proteins Regulate Epigenetic Silencing by Modulating DNA Methylation and Histone Modification in Cooperation with MET1

ATP-binding mode including a carbamoylated lysine and two Mg2+ ions, and substrate-binding mode in Acinetobacter baumannii MurF

Purification, crystallization and preliminary X‐ray crystallographic analysis of the UDP‐N‐acetylmuramoyl‐tripeptide‐D‐alanyl‐D‐alanine ligase (MurF) from Acinetobacter baumannii

Expression, crystallization and preliminary X‐ray crystallographic analysis of D‐alanine‐D‐alanine ligase from OXA‐23‐producing Acinetobacter baumannii K0420859

Crystal structures of d-alanine-d-alanine ligase from Xanthomonas oryzae pv. oryzae alone and in complex with nucleotides

Protection against Vibrio vulnificus infection by active and passive immunization with the C-terminal region of the RtxA1/MARTXVv protein

Overexpression of AtCHX24, a member of the cation/H+ exchangers, accelerates leaf senescence in Arabidopsis thaliana

Characterization of monoclonal antibodies targeting the RtxA1 toxin of Vibrio vulnificus

Three positive regulators of leaf senescence in Arabidopsis, ORE1, ORE3 and ORE9, play roles in crosstalk among multiple hormone-mediated senescence pathways

Characterization of behavioral and endocrine effects of LSD on zebrafish

Analyzing habituation responses to novelty in zebrafish (Danio rerio)

The effects of chronic social defeat stress on mouse self-grooming behavior and its patterning

Modeling withdrawal syndrome in zebrafish

Development and characterization of non-glycosylated E and NS1 mutant viruses as a potential candidate vaccine for West Nile virus

Downregulation of Wnt-Mediated ROS generation is causally implicated in leprechaunism

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