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It is shown that in response to an anti-tumour compound of the alkylating type, imidazene, combined with bihelical yeast RNA, some characteristics of tumour DNA (the content of 5-methylcytosine, the temperature and the melting interval) approach those of DNA of the liver of healthy animals better than on exposure to imidazene alone.
Spectrophotometry and microcalorimetry have been employed to investigate the melting of DNA complexes with the anti-tumour compound mitoxanthrone for ionic strengths of 0.11 and 0.011 M NaCl. It is shown that at 0.011 M NaCl the dependence of the melting point (T m ) on the concentration of mitoxanthrone passes through a minimum, and T m falls in the region where there is one mitoxanthrone...