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The HIF transcription factor promotes adaptation to hypoxia and stimulates the growth of certain cancers, including triple-negative breast cancer (TNBC). The HIFα subunit is usually prolyl-hydroxylated by EglN family members under normoxic conditions, causing its rapid degradation. We confirmed that TNBC cells secrete glutamate, which we found is both necessary and sufficient for the paracrine induction...
1‐Deoxy‐d‐xylulose 5‐phosphate (DXP) synthase catalyzes the formation of DXP from pyruvate and d‐glyceraldehyde 3‐phosphate (GraP) in a thiamin diphosphate‐dependent manner, and is the first step in the essential pathway to isoprenoids in human pathogens. Understanding the mechanism of this unique enzyme is critical for developing new anti‐infective agents that selectively target isoprenoid biosynthesis...
Bath salts commonly contain multiple synthetic drugs, and their toxic effects are largely the same as those seen in patients who have taken large doses of amphetamines. Bath salts can be ingested, smoked, or administered intravenously. Their use is on the rise and is responsible for a large number of emergency department visits.Our case series involved five patients (six hospital courses) who presented...
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