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We investigated the genetic structure and population frequency of an Alu repeat dimorphism (absence or presence) located near the OR12D2 gene within the olfactory receptor gene region telomeric of the alpha HLA class I region (HLA‐J, ‐A, ‐G, ‐F). The structurally polymorphic Alu insertion (POALIN) locus rs33972478 that we designated as AluOR and its allele and haplotype frequencies and association...
Super high‐resolution single molecule sequence‐based typing (SS‐SBT) is a human leukocyte antigen (HLA) DNA typing method to the field 4 level of allelic resolution (formerly known as eight‐digit typing) to efficiently detect new and null alleles without phase ambiguity by combination of long ranged polymerase chain reaction (PCR) amplification and next‐generation sequencing (NGS) technologies. We...
Current human leukocyte antigen (HLA) DNA typing methods such as the sequence‐based typing (SBT) and sequence‐specific oligonucleotide (SSO) methods generally yield ambiguous typing results because of oligonucleotide probe design limitations or phase ambiguity for HLA allele assignment. Here we describe the development and application of the super high‐resolution single‐molecule sequence‐based typing...
We investigated structurally polymorphic Alu insertions (POALINs) at five loci in the major histocompatibility complex (MHC) class I genomic region to determine their allele and haplotype frequencies and associations with the human leukocyte antigen (HLA)‐A, ‐B, and ‐C genes in three populations, the Australian Caucasians, Japanese, and African Americans. The POALINs varied in allelic frequency between...
A simple and novel genotyping method was developed to detect alleles at the swine leukocyte antigen (SLA)‐DRB1 and ‐DQB1 class II loci by using polymerase chain reaction (PCR)–fluorescently labeled sequence‐specific oligonucleotide probes (SSOPs) and Luminex 100 xMAP detection. The PCR–SSOP–Luminex method exhibited accuracy of 95% for both SLA‐DRB1 and ‐DQB1 in 6 homozygous and 16 heterozygous pig...
We investigated polymorphic Alu insertion (POALIN) frequencies at five loci in the major histocompatibility complex (MHC) class II genomic region to determine their allele and haplotype frequencies and associations with the human leukocyte antigen (HLA)‐DRB1 and ‐DQB1 genes for 100 Japanese, 174 Australian Caucasians and 67 HLA reference cell lines obtained from different ethnic groups. The POALIN...
We describe the generation and analysis of an integrated sequence map of a 2.4-Mb region of pig chromosome 7, comprising the classical class I region, the extended and classical class II regions, and the class III region of the major histocompatibility complex (MHC), also known as swine leukocyte antigen (SLA) complex. We have identified and manually annotated 151 loci, of which 121 are known genes...
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