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Idiopathic pulmonary fibrosis (IPF) is a disease of progressive scarring caused by excessive extracellular matrix (ECM) deposition and activation of α‐SMA‐expressing myofibroblasts. Human antigen R (HuR) is an RNA binding protein that promotes protein translation. Upon translocation from the nucleus to the cytoplasm, HuR functions to stabilize messenger RNA (mRNA) to increase protein levels. However,...
Introduction
Patients with Duchenne muscular dystrophy (DMD) frequently undergo mechanical ventilation (MV) for treatment of hypoventilation, but the susceptibility of the dystrophic diaphragm to ventilator‐induced diaphragmatic dysfunction (VIDD) has not been examined.
Methods
Dystrophic mice (mdx—genetic homolog of DMD) were assigned to non‐ventilated control (CTL) and MV (for 6 hours) groups...
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