Muscle & Nerve

We examined reactive oxygen species as upstream activators of nuclear factor κB; (NF‐κB) and forkhead box O (Foxo) in skeletal muscle during disuse atrophy. Catalase, an enzyme that degrades H₂O₂, was overexpressed in soleus muscles via plasmid injection prior to 7 days of hindlimb immobilization. The increased catalase activity abolished immobilization‐induced transactivation of both NF‐κB and Foxo...

article

Calendar of events

Muscle & Nerve > 41 > 1 > 154 - 154

article

AANEM news and comments

Muscle & Nerve > 41 > 1 > 155 - 159

article

Myokymic discharges in amyotrophic lateral sclerosis (ALS): A rare electrophysiologic finding?

Nathaniel R. Whaley, Devon I. Rubin

Muscle & Nerve > 41 > 1 > 107 - 109

Myokymic discharges (MDs) are uncommonly recognized in amyotrophic lateral sclerosis (ALS). The electrophysiologic findings in 96 ALS patients were retrospectively reviewed. MDs were found in 5.2% of patients, in 0.81% of total muscles examined (8.2% cranial muscles vs. 0.15% limb muscles). The higher frequency of MDs in cranial muscles suggests a difference in the metabolic environment or other mechanism...

article

Reviewer Acknowledgments

Lawrence H Phillips

Muscle & Nerve > 41 > 1 > 2 - 4

article

From the editor: January 2010

Lawrence H Phillips

Muscle & Nerve > 41 > 1 > 1 - 1

article

Facioscapulohumeral muscular dystrophy: Do neurotrophins play a role?

Francesco Angelucci, Luca Colantoni

Muscle & Nerve > 41 > 1 > 120 - 127

Although the molecular defect of facioscapulohumeral muscular dystrophy (FSHD) is well established and involves the contraction of the polymorphic 3.3 kb D4Z4 repeat on the subtelomeric region of chromosome 4q35, the pathologic effects of this deletion remain largely unknown. As a consequence, no specific treatment for FSHD is at present available. Thus, there is the need to explore new areas in an...

article

Conduction block of peripheral nerve using high‐frequency alternating currents delivered through an intrafascicular electrode

D. Michael Ackermann, Emily L. Foldes, Niloy Bhadra, Kevin L. Kilgore

Muscle & Nerve > 41 > 1 > 117 - 119

Many diseases are characterized by undesired or pathological neural activity. The local delivery of high‐frequency currents has been shown to be an effective method for blocking neural conduction in peripheral nerves and may provide a therapy for these conditions. To date, all studies of high‐frequency conduction block have utilized extraneural (cuff) electrodes to achieve conduction block. In this...

article

Neuronal and glial cerebrospinal fluid protein biomarkers are elevated after West Nile Virus infection

A. Petzold, M. Groves, A.A. Leis, F. Scaravilli, more

Muscle & Nerve > 41 > 1 > 42 - 49

Neurotrophic West Nile virus (WNV) disease is a severe arbovirus infection in which neuronal loss is the likely anatomical substrate for the high morbidity and mortality. We investigated whether cerebrospinal fluid (CSF) protein biomarkers were elevated in vivo and related to disease severity in patients with WNV infection. This exploratory study included 114 patients (24 acute WNV, 77 noninflammatory...

article

Primary AL amyloid polyneuropathy successfully treated with high‐dose melphalan followed by autologous stem cell transplantation

Nagaaki Katoh, Masayuki Matsuda, Takuhiro Yoshida, Masahide Yazaki, more

Muscle & Nerve > 41 > 1 > 138 - 143

We report 2 patients with polyneuropathy associated with amyloid derived from light chains (AL) who were treated successfully with high‐dose melphalan followed by autologous peripheral blood stem cell transplantation (HDM/SCT). Neuropathic symptoms improved in conjunction with normalization of serum‐free light chains. In addition to amyloid deposits in tissues, an amyloidogenic light chain itself...

article

Probabilistic muscle characterization using QEMG: Application to neuropathic muscle

L.J. Pino, D.W. Stashuk, S.G. Boe, T.J. Doherty

Muscle & Nerve > 41 > 1 > 18 - 31

Clinicians who use electromyographic (EMG) signals to help determine the presence or absence of abnormality in a muscle often, with varying degrees of success, evaluate sets of motor unit potentials (MUPs) qualitatively and/or quantitatively to characterize the muscle in a clinically meaningful way. The resulting muscle characterization can be improved using automated analysis. As such, the intent...

article

Rippling muscle disease: Variable phenotype in a family with five afflicted members

Christian Jacobi, Ruth Ruscheweyh, Matthias Vorgerd, Marc‐André Weber, more

Muscle & Nerve > 41 > 1 > 128 - 132

We report a family with rippling muscle disease (RMD) who had an autosomal dominant mode of inheritance. The father, mother, and one daughter proved to be heterozygous, and two sons were homozygous for the A92T mutation of the caveolin‐3 gene. The cardinal features of RMD, particularly percussion‐induced rapid contractions, muscle mounding, and muscle rippling, varied considerably among these subjects...

article

Normal values for quantitative muscle ultrasonography in adults

Ilse M.P. Arts, Sigrid Pillen, H. Jurgen Schelhaas, Sebastiaan Overeem, more

Muscle & Nerve > 41 > 1 > 32 - 41

Ultrasonography can detect structural muscle changes caused by neuromuscular disease. Quantitative analysis is the preferred method to determine if ultrasound findings are within normal limits, but normative data are incomplete. The purpose of this study was to provide normative muscle ultrasonography data for muscle thickness and echo intensity for five different muscle groups in adults. Bilateral...

article

Impairment of upper trapezius branch of the spinal accessory nerve during bypass grafting: A stretch injury?

Zelal Keleş, Murat Zinnuroğlu, Mehmet Beyazova

Muscle & Nerve > 41 > 1 > 144 - 147

Internal jugular vein catheterization has been implicated in spinal accessory nerve (SAN) injuries after coronary artery bypass grafting (CABG). Stretch injury due to prolonged positioning during CABG has also been proposed as another mechanism of injury. Herein we describe a male patient with left shoulder pain and abduction difficulty following CABG, who displayed electromyographic abnormalities...

article

Voluntary activation in the triceps brachii at short and long muscle lengths

Arthur J. Cheng, Charles L. Rice

Muscle & Nerve > 41 > 1 > 63 - 70

The aim was of this study was to determine whether voluntary activation calculated using the interpolated twitch technique (ITT) would be underestimated by muscle length–induced changes in the twitch amplitude evoked at rest after maximum voluntary contraction (MVC) in the elbow extensors. In 12 healthy men, calculated voluntary activations were compared at short (20° of elbow flexion) and long muscle...

article

Involvement of PI3K/Akt/TOR pathway in stretch‐induced hypertrophy of myotubes

Nobuaki Sasai, Nobuhide Agata, Masumi Inoue‐Miyazu, Keisuke Kawakami, more

Muscle & Nerve > 41 > 1 > 100 - 106

Skeletal muscle cells are hypertrophied by mechanical stresses, but the underlying molecular mechanisms are not fully understood. Two signaling pathways, phosphatidylinositol 3‐kinase (PI3K)/Akt to target of rapamycin (TOR) and extracellular signal–regulated kinase kinase (MEK) to extracellular signal–regulated kinase (ERK), have been proposed to be involved in muscle hypertrophy. In this study we...

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INFONA - science communication portal

Muscle & Nerve

Table of contents

Central nervous system involvement in axonal Charcot–Marie–Tooth disease

Between the covers: This month's main articles

Magnetic resonance imaging diagnosis of panniculitis in dermatomyositis

Ros‐mediated activation of NF‐κB and Foxo during muscle disuse

Calendar of events

AANEM news and comments

Myokymic discharges in amyotrophic lateral sclerosis (ALS): A rare electrophysiologic finding?

Reviewer Acknowledgments

From the editor: January 2010

Facioscapulohumeral muscular dystrophy: Do neurotrophins play a role?

Conduction block of peripheral nerve using high‐frequency alternating currents delivered through an intrafascicular electrode

Neuronal and glial cerebrospinal fluid protein biomarkers are elevated after West Nile Virus infection

Primary AL amyloid polyneuropathy successfully treated with high‐dose melphalan followed by autologous stem cell transplantation

Probabilistic muscle characterization using QEMG: Application to neuropathic muscle

Rippling muscle disease: Variable phenotype in a family with five afflicted members

Normal values for quantitative muscle ultrasonography in adults

Impairment of upper trapezius branch of the spinal accessory nerve during bypass grafting: A stretch injury?

Voluntary activation in the triceps brachii at short and long muscle lengths

Involvement of PI3K/Akt/TOR pathway in stretch‐induced hypertrophy of myotubes

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