Search results for: Jiao Xue

Items from 1 to 20 out of 66 results

article

Bioactivity of hamamelitannin, flavokawain A, and triacetyl resveratrol as natural compounds: Molecular docking study, anticolon cancer, and anti‐Alzheimer potentials

Ming Zhang, Jiao Xue, Xiao Chen, Fahmy G. Elsaid, more

Biotechnology and Applied Biochemistry > 70 > 2 > 730 - 745

In this study, we worked on anticolon cancer effects and anti‐Alzheimer's disease with molecular docking studies. Hamamelitannin, flavokawain A, and triacetyl resveratrol compounds showed good inhibitory activities on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes. The inhibition effects of flavokawain A, hamamelitannin, and triacetyl resveratrol on AChE and BuChE enzymes were...

article

Vortex‐assisted dispersive liquid‐phase microextraction for the analysis of main active compounds from Zi‐Cao‐Cheng‐Qi decoction based on a hydrophobic deep eutectic solvent

Jiao Xue, Li Yang, Xuan Chen, Xiao‐Hong Bai, more

Journal of Separation Science > 44 > 24 > 4376 - 4383

In this study, a vortex‐assisted hydrophobic deep eutectic solvent dispersive liquid‐phase microextraction was developed and used for the extraction and preconcentration of six main active compounds in Zi‐Cao‐Cheng‐Qi decoction. The deep eutectic solvent, prepared by mixing tetrabutylammonium chloride and hexanoic acid at a molar ratio of 1:1, was added to the sample solution containing the analytes...

article

A novel palmitic acid hydroxy stearic acid (5‐PAHSA) plays a neuroprotective role by inhibiting phosphorylation of the m‐TOR‐ULK1 pathway and regulating autophagy

Jian‐tao Wang, Zhong‐yu Yu, Ying‐hong Tao, Ying‐chao Liu, more

CNS Neuroscience & Therapeutics > 27 > 4 > 484 - 496

Aims Type 2 diabetes mellitus (T2DM) can lead to brain dysfunction and a series of neurological complications. Previous research demonstrated that a novel palmitic acid (5‐PAHSA) exerts effect on glucose tolerance and chronic inflammation. Autophagy was important in diabetic‐related neurodegeneration. The aim of the present study was to investigate whether 5‐PAHSA has specific therapeutic effects...

article

Comparisons on characteristics and mechanisms of the decadal megadroughts over eastern China between MCA and LIA

Jiao Xue, Liang Ning, Yanmin Qin, Kefan Chen, more

International Journal of Climatology > 41 > 3 > 1985 - 1997

In this study, simulations of 13 all‐forcing experiments from the Community Earth System Model Last Millennium Ensemble (CESM‐LME) archive were used to investigate the different spatiotemporal characteristics and corresponding mechanisms of the decadal megadroughts over the eastern China during two typical periods in the past millennium, that is, Medieval Climate Anomaly (MCA) and Little Ice Age (LIA)...

article

BAK1‐mediated phosphorylation of canonical G protein alpha during flagellin signaling in Arabidopsis

Jiao Xue, Ben‐Qiang Gong, Xinran Yao, Xiangjuan Huang, more

Journal of Integrative Plant Biology > 62 > 5 > 690 - 701

Heterotrimeric G proteins consisting of Gα, Gβ and Gγ are conserved signaling hubs in eukaryotes. Without analogs to canonical animal G protein‐coupled receptors, plant cells are thought to use RGS1 and a yet unknown mechanism to regulate the activity of Gα. Meanwhile, the exact role of canonical Gα in plant innate immunity remains controversial. Here, we report multiple immune deficiencies in the...

article

Clinical and genetic features in pyridoxine‐dependent epilepsy: a Chinese cohort study

Xianru Jiao, Jiao Xue, Pan Gong, Ye Wu, more

Developmental Medicine & Child Neurology > 62 > 3 > 315 - 321

Aim To characterize the clinical and genetic characteristics of a large cohort of patients with pyridoxine‐dependent epilepsy (PDE). Method We retrospectively collected clinical and genetic information of 33 (15 males, 18 females; mean [SD] age 4y 11mo [2y 5mo]; 1y 3mo–10y 4mo) patients with PDE from 31 unrelated families at a single centre. Results There were many types of seizures, with focal...

article

Glucose‐6‐Phosphate Dehydrogenase from the Oleaginous Microalga Nannochloropsis Uncovers Its Potential Role in Promoting Lipogenesis

Jiao Xue, Ting‐Ting Chen, Jian‐Wei Zheng, Srinivasan Balamurugan, more

Biotechnology Journal > 15 > 2 > n/a - n/a

Microalgae have long been considered as potential biological feedstock for the production of wide array of bioproducts, such as biofuel feedstock because of their lipid accumulating capability. However, lipid productivity of microalgae is still far below commercial viability. Here, a glucose‐6‐phosphate dehydrogenase from the oleaginous microalga Nannochloropsis oceanica is identified and heterologously...

article

Three‐phase hollow‐fiber liquid‐phase microextraction based on deep eutectic solvent as acceptor phase for extraction and preconcentration of main active compounds in a traditional Chinese medicinal formula

Jiao Xue, Run‐qin Wang, Xuan Chen, Shuang Hu, more

Journal of Separation Science > 42 > 13 > 2239 - 2246

A three‐phase hollow‐fiber liquid‐phase microextraction based on deep eutectic solvent as acceptor phase was developed and coupled with high‐performance capillary electrophoresis for the simultaneous extraction, enrichment, and determination of main active compounds (hesperidin, honokiol, shikonin, magnolol, emodin, and β,β′‐dimethylacrylshikonin) in a traditional Chinese medicinal formula. In this...

article

Epigallocatechin‐3‐gallate inhibits proliferation and induces apoptosis in odontogenic keratocyst keratinocytes

Shao-Bin Yang, Bao-Xing Pang, Jiao Xue, Rong-Tao Yuan

Oral Diseases > 25 > 4 > 1175 - 1184

Objective The aim of this study was to investigate the effects of epigallocatechin‐3‐gallate on the proliferation and apoptosis of odontogenic keratocyst (OKC) keratinocytes in vitro. Materials and methods Keratinocytes isolated from the epithelial lining of the OKC were cultured in keratinocyte serum‐free medium and identified by CK10, CK14, pan‐cytokeratin and vimentin immunofluorescence staining...

article

Pharmacokinetics of the novel COX‐2 selective inhibitor vitacoxib in cats: The effects of feeding and dose

Jianzhong Wang, Xiaohui Gong, Jiao Xue, Suxia Zhang, more

Journal of Veterinary Pharmacology and Therapeutics > 42 > 3 > 294 - 299

The purpose of this study was to determine the pharmacokinetics and dose‐scaling model of vitacoxib in either fed or fasted cats following either oral or intravenous administration. The concentration of the drug was quantified by UPLC‐MS/MS on plasma samples. Relevant parameters were described using noncompartmental analysis (WinNonlin 6.4 software). Vitacoxib is relatively slowly absorbed and eliminated...

article

Pharmacokinetics of vitacoxib in rabbits after intravenous and oral administration

Jianzhong Wang, Jiao Xue, Lu Zhang, Suxia Zhang, more

Journal of Veterinary Pharmacology and Therapeutics > 42 > 3 > 368 - 371

This study describes the pharmacokinetics of vitacoxib in healthy rabbits following administration of 10 mg/kg intravenous (i.v.) and 10 mg/kg oral. Twelve New Zealand white rabbits were randomly allocated to two equally sized treatment groups. Blood samples were collected at predetermined times from 0 to 36 hr after treatment. Plasma drug concentrations were determined using UPLC‐MS/MS. Pharmacokinetic...

article

Comparative study of different molecular weight pullulan productions by Aureobasidium pullulans CGMCC No.11602

Chao An, Sai-jian Ma, Wen-jiao Xue, Chen Liu, more

00003 Biotech > 2019 > 9 > 4 > 1-7

Pullulan productions by Aureobasidium pullulans CGMCC No.11602 were conducted using the initial culture (IC) medium and the optimized culture (OC) medium, respectively, in which pullulan with significantly different molecular weights was obtained. Under the IC medium condition, the pullulan molecular weight (M_w) reached 288,403 Da with a yield of 64.12 g/L after 96 h fermentation period. However,...

article

The pharmacokinetics of moxidectin following intravenous and topical administration to swine

Hongzhi Xiao, Haoyuan Peng, Ting Zhao, Jingyuan kong, more

Journal of Veterinary Pharmacology and Therapeutics > 42 > 1 > 111 - 115

The pharmacokinetic parameters of moxidectin (MXD) after intravenous and pour‐on (topical) administration were studied in sixteen pigs at a single dose of 1.25 and 2.5 mg/kg BW (body weight), respectively. Blood samples were collected at pretreatment time (0 hr) over 40 days. The plasma kinetics were analyzed by WinNonlin 6.3 software through a noncompartmental model. For intravenous administration...

article

Evaluation of pharmacokinetic properties of vitacoxib in fasted and fed horses

Jianzhong Wang, Jiao Xue, Jingyuan Kong, Jing Li, more

Journal of Veterinary Pharmacology and Therapeutics > 41 > 6 > 843 - 847

The pharmacokinetic properties of vitacoxib have not been established completely; current dosage recommendations are based on clinical experiences. The primary objective of this study was to describe plasma concentrations and characterize the pharmacokinetics of vitacoxib formulation following oral administrations in horses. Also, the effect of the state of stomach contents on the absorption of vitacoxib...

article

The role of diatom glucose-6-phosphate dehydrogenase on lipogenic NADPH supply in green microalgae through plastidial oxidative pentose phosphate pathway

Jiao Xue, Ting-Ting Chen, Jian-Wei Zheng, Srinivasan Balamurugan, more

Applied Microbiology and Biotechnology > 2018 > 102 > 24 > 10803- 10815

Commercial production of biofuel from oleaginous microalgae is often impeded by their slow growth rate than other fast-growing algal species. A promising strategy is to genetically engineer the fast-growing algae to accumulate lipids by expressing key lipogenic genes from oleaginous microalgae. However, lacking of strong expression cassette to transform most of the algal species and potential metabolic...

article

Sodium dodecyl sulfate sensitized switchable solvent liquid‐phase microextraction for the preconcentration of protoberberine alkaloids in Rhizoma coptidis

Shuang Hu, Jiao Xue, Xiao Yang, Xuan Chen, more

Journal of Separation Science > 41 > 18 > 3614 - 3621

A sodium dodecyl sulfate sensitized switchable solvent liquid‐phase microextraction method was developed and applied to the preconcentration of active alkaloids in Rhizoma coptidis followed by high performance liquid chromatography determination. Before extraction, nonionic triethylamine was converted to its cationic form in the presence of carbon dioxide. Then, the ionic solvent carrying target analytes...

article

Does Risk‐taking Promote New Product Development Performance? An Environmental Dynamism Perspective

Jiao Xue, Saixing Zeng, Xiaohua Meng, Yunfeng Peng

Asia‐Pacific Journal of Financial Studies > 47 > 3 > 381 - 400

Using an “entrepreneurial orientation–performance” framework and environmental contingency theory, this study proposes and empirically explores a theoretical framework for understanding the impacts of risk‐taking and environmental dynamism on new product development (NPD) performance in emerging markets. We deepen the analysis of environmental dynamism into customer, competitor, supplier, institutional...

article

Clinical characteristics of two cohorts of infantile spasms: response to pyridoxine or topiramate monotherapy

Jiao Xue, Ping Qian, Hui Li, Ye Wu, more

World Journal of Pediatrics > 2018 > 14 > 3 > 290-297

Background Infantile spasms (IS) was an epileptic disease with varied treatment widely among clinicians. Here, we aimed to compare and analyze the clinical characteristics of IS response to pyridoxine or topiramate monotherapy (TPM control IS). Methods The clinical manifestations, treatment processes and outcomes were analyzed in 11 pyridoxine responsive IS and 17 TPM-control IS. Results Of the...

article

Myoclonic epilepsy in infancy with preceding or concurrent afebrile generalized tonic-clonic seizures in Chinese children

Zhixian Yang, Hui Li, Jiao Xue, Ping Qian, more

Brain and Development > 2017 > 39 > 10 > 828-835

To investigate the general characteristics and the category of myoclonic epilepsy in infancy (MEI) with or without afebrile generalized tonic-clonic seizures (GTCS).Thirty-three children were retrospectively recruited from approximately 42,814 video-electroencephalogram (VEEG) recordings monitored in our department over last nearly 10years. Myoclonic seizures (MS) must be identified by VEEG in all...

article

Early childhood myoclonic epilepsy: An independent genetic generalized epilepsy with myoclonic seizures as the main seizure type

Zhixian Yang, Jiao Xue, Hui Li, Ping Qian, more

Clinical Neurophysiology > 2017 > 128 > 9 > 1656-1663

To elucidate the characteristics of the myoclonic seizures alone, or predominant myoclonus combined with generalized tonic-clonic seizures (GTCS) and/or absences, in early childhood, and discuss its classification.Forty-two children were retrospectively recruited between January 2006 and June 2015.The mean age of seizure onset was 40.5months. They were divided into 4 groups: myoclonic seizures alone;...

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INFONA - science communication portal

Search results for: Jiao Xue

Bioactivity of hamamelitannin, flavokawain A, and triacetyl resveratrol as natural compounds: Molecular docking study, anticolon cancer, and anti‐Alzheimer potentials

Vortex‐assisted dispersive liquid‐phase microextraction for the analysis of main active compounds from Zi‐Cao‐Cheng‐Qi decoction based on a hydrophobic deep eutectic solvent

A novel palmitic acid hydroxy stearic acid (5‐PAHSA) plays a neuroprotective role by inhibiting phosphorylation of the m‐TOR‐ULK1 pathway and regulating autophagy

Comparisons on characteristics and mechanisms of the decadal megadroughts over eastern China between MCA and LIA

BAK1‐mediated phosphorylation of canonical G protein alpha during flagellin signaling in Arabidopsis

Clinical and genetic features in pyridoxine‐dependent epilepsy: a Chinese cohort study

Glucose‐6‐Phosphate Dehydrogenase from the Oleaginous Microalga Nannochloropsis Uncovers Its Potential Role in Promoting Lipogenesis

Three‐phase hollow‐fiber liquid‐phase microextraction based on deep eutectic solvent as acceptor phase for extraction and preconcentration of main active compounds in a traditional Chinese medicinal formula

Epigallocatechin‐3‐gallate inhibits proliferation and induces apoptosis in odontogenic keratocyst keratinocytes

Pharmacokinetics of the novel COX‐2 selective inhibitor vitacoxib in cats: The effects of feeding and dose

Pharmacokinetics of vitacoxib in rabbits after intravenous and oral administration

Comparative study of different molecular weight pullulan productions by Aureobasidium pullulans CGMCC No.11602

The pharmacokinetics of moxidectin following intravenous and topical administration to swine

Evaluation of pharmacokinetic properties of vitacoxib in fasted and fed horses

The role of diatom glucose-6-phosphate dehydrogenase on lipogenic NADPH supply in green microalgae through plastidial oxidative pentose phosphate pathway

Sodium dodecyl sulfate sensitized switchable solvent liquid‐phase microextraction for the preconcentration of protoberberine alkaloids in Rhizoma coptidis

Does Risk‐taking Promote New Product Development Performance? An Environmental Dynamism Perspective

Clinical characteristics of two cohorts of infantile spasms: response to pyridoxine or topiramate monotherapy

Myoclonic epilepsy in infancy with preceding or concurrent afebrile generalized tonic-clonic seizures in Chinese children

Early childhood myoclonic epilepsy: An independent genetic generalized epilepsy with myoclonic seizures as the main seizure type

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