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We identified CD8+ CD122+ regulatory T cells (CD8+ CD122+Treg cells) and reported their importance in maintaining immune homeostasis. The absence of CD8+ CD122+Treg cells has been shown to lead to severe systemic autoimmunity in several mouse models, including inflammatory bowel diseases and experimental autoimmune encephalomyelitis. The T‐cell receptors (TCRs) expressed on CD8+ CD122+Treg cells recognize...