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Matching of human leukocyte antigen (HLA) alleles between donors and recipients plays a major role in hematopoietic stem cell transplantation (HSCT). Null or questionably expressed HLA allelic variants are a major issue in HLA matching, because the aberrant expression of such alleles can have a major impact on the outcome of HSCT and/or its complications such as graft‐versus‐host disease. The goal...
SCID-X1 ist eine X-chromosomal vererbte Form der schweren kombinierten Immundefizienz, die durch inaktivierende Mutationen im IL2RG-Gen verursacht wird. Dieses Gen kodiert für die gemeinsame γ-Kette der Interleukinrezeptoren (Interleukin 2 receptor common gamma chain, Interleukin-2-Rezeptor-γ-Kette, IL2RG). Die betroffenen Jungen können 2 Haupttypen der Effektorzellen des Immunsystems nicht entwickeln...
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