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ObjectiveIncreased inflammation and pain are inseparable parts of knee osteoarthritis (OA) that may lead to disuse of the affected limb. The aim of this study was to examine the effects of knee OA on inflammation‐ and atrophy‐related genes and proteins in the vastus lateralis muscle of patients with knee OA.
MethodsNineteen patients with knee OA and 14 asymptomatic control subjects matched for age...
The JAK/STAT signaling pathway is essential for myogenic regeneration and is regulated by a diverse range of ligands, including interleukin‐6 (IL‐6) and platelet‐derived growth factor‐BB (PDGF‐BB). Our aim was to evaluate the responsiveness of IL‐6 and PDGF‐BB to intense exercise, along with STAT3 activation, before and after 12 weeks of resistance training. In young men, IL‐6 and PDGF‐BB protein...
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