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AimIn this study, we investigated the regulatory network of the key and rate‐limiting enzyme of cholesterol biosynthetic pathway, the 3‐hydroxy 3‐methylglutaryl coenzyme A reductase (HMGR) in different brain regions, to add new insight about lipid metabolism and physiology in the central nervous system (CNS).
MethodsHMGR levels and activation state and the proteins involved in the enzyme regulatory...