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There is a growing clinical demand for the development of replacement constructs that can emulate native tendon tissue. In this study, a technique to synthesize scaffold-free, single tendon fibers using micro-molded channels is presented. This mold-based channel fabrication technique replaces our previously established laser-based technique, to provide greatly improved reproducibility in 3D channel...
Collagen is believed to be one of the principal load bearing components of skin. This implies that deformation of collagen microfibrils play an important role in determining the extent of skin deformation under applied loads. We have developed a novel technique for generating internal strain maps of bundles of collagen microfibrils in the skin. The technique relies on digital image correlation (DIC)...
Microbead-based biosensors, lab-on-a-chip devices, optoelectronics, and engineered tissue constructs pose a difficult challenge for direct-write technologies. The fabrication of microbead arrays with single-elements requires a highly-integrated technique. We demonstrate Laser Forward Transfer (LFT) as an ideal technique to target single microbeads with widely disparate properties, for real-time transfer...
Force Depression (FD) describes the decrease in steady-state force production after active shortening in skeletal muscle. Despite being well characterized in skeletal muscle, the underlying mechanism remains unknown. The Drosophila jump muscle, tergal depressor of the trochanter (TDT), has recently been demonstrated to be mechanically similar to mammalian skeletal muscle, and due to the genetic simplicity...
We have developed a scaffold-free, cell-based, single fiber approach toward tissue engineered tendon. This method provides a culture system in which key aspects of embryonic tenogenesis may be replicated, such as high initial cell density, cell-cell adhesion, and dynamic mechanical cues. Through the application of embryonic development inspired growth factors and mechanical stimulation, we ultimately...
Laser direct-write (LDW) is a biofabrication method capable of rapidly creating precise patterns of viable cells. While previous studies have successfully printed cells to polystyrene Petri dishes, here we have adapted LDW to printing both human dermal fibroblasts and mouse embryonic stem cells (mESCs) to cover slips, allowing more efficient use of culture reagents. Viability of both cell types was...
AbstractRecent experiments in rat medial collateral ligament revealed that the rate of stress relaxation is strain dependent and the rate of creep is stress dependent. This nonlinear behavior requires a more general description than the separable quasilinear viscoelasticity theory commonly used in tissue biomechanics. The purpose of this study was to determine whether the nonlinear theory of Schapery...
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