Search results for: Silvia Turroni

Items from 1 to 20 out of 33 results

article

Role of gut microbiome in the outcome of lymphoma patients treated with checkpoint inhibitors—The MicroLinf Study

Beatrice Casadei, Gabriele Conti, Monica Barone, Silvia Turroni, more

Hematological Oncology > 42 > 5 > n/a - n/a

Biomarkers for immune checkpoint inhibitors (ICIs) response and resistance include PD‐L1 expression and other environmental factors, among which the gut microbiome (GM) is gaining increasing interest especially in lymphomas. To explore the potential role of GM in this clinical issue, feces of 30 relapsed/refractory lymphoma (Hodgkin and primary mediastinal B‐cell lymphoma) patients undergoing ICIs...

article

Cerrado and Pantanal fruit flours affect gut microbiota composition in healthy and post‐COVID‐19 individuals: an in vitro pilot fermentation study

Carolina Saori Ishii Mauro, Maryame Kadiri Hassani, Monica Barone, Maria Teresa Esposito, more

International Journal of Food Science & Technology > 58 > 8 > 4495 - 4510

Cerrado and Pantanal plants can provide fruits with high nutritional value and antioxidants. This study aims to evaluate four fruit flours (from jatobá pulp, cumbaru almond, bocaiuva pulp and bocaiuva almond) and their effects on the gut microbiota in healthy (HD) and post‐COVID‐19 individuals (PC). An in vitro batch system was carried out, the microbiota was analysed by 16S rRNA amplicon sequencing...

article

Gut microbiome–micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins?

Monica Barone, Federica D'Amico, Patrizia Brigidi, Silvia Turroni

BioFactors > 48 > 2 > 307 - 314

Micronutrients, namely, vitamins and minerals, are necessary for the proper functioning of the human body, and their deficiencies can have dramatic short‐ and long‐term health consequences. Among the underlying causes, certainly a reduced dietary intake and/or poor absorption in the gastrointestinal tract play a key role in decreasing their bioavailability. Recent evidence from clinical and in vivo...

article

The gut microbiome in pediatric patients undergoing allogeneic hematopoietic stem cell transplantation

Riccardo Masetti, Daniele Zama, Davide Leardini, Edoardo Muratore, more

Pediatric Blood & Cancer > 67 > 12 > n/a - n/a

The gut microbiome (GM) has been associated with different clinical outcomes in the context of allogeneic hematopoietic stem cell transplantation (HSCT). Large multicenter cohort studies in adults have found significant correlations with overall survival, relapse, and incidence of complications. Moreover, GM is already a promising target for therapeutic interventions. However, few data are available...

article

HumanMycobiomeScan: a new bioinformatics tool for the characterization of the fungal fraction in metagenomic samples

Matteo Soverini, Silvia Turroni, Elena Biagi, Patrizia Brigidi, more

BMC Genomics > 2019 > 20 > 1 > 1-7

Background Modern metagenomic analysis of complex microbial communities produces large amounts of sequence data containing information on the microbiome in terms of bacterial, archaeal, viral and eukaryotic composition. The bioinformatics tools available are mainly devoted to profiling the bacterial and viral fractions and only a few software packages consider fungi. As the human fungal microbiome...

article

Early gut microbiota signature of aGvHD in children given allogeneic hematopoietic cell transplantation for hematological disorders

Elena Biagi, Daniele Zama, Simone Rampelli, Silvia Turroni, more

BMC Medical Genomics > 2019 > 12 > 1 > 1-11

Background The onset of acute Graft-versus-Host Disease (aGvHD) has been correlated with the gut microbiota (GM) composition, but experimental observations are still few, mainly involving cohorts of adult patients. In the current scenario where fecal microbiota transplantation has been used as a pioneer therapeutic approach to treat steroid-refractory aGvHD, there is an urgent need to expand existing...

article

Dietary geraniol ameliorates intestinal dysbiosis and relieves symptoms in irritable bowel syndrome patients: a pilot study

Fernando Rizzello, Chiara Ricci, Michela Scandella, Elena Cavazza, more

BMC Complementary and Alternative Medicine > 2018 > 18 > 1 > 1-11

Background (Trans)-3,7-Dimethyl-2,6-octadien-1-ol, commonly called geraniol (Ge-OH), is an acyclic monoterpene alcohol with well-known anti-inflammatory and antimicrobial properties. Ge-OH is a non-toxic compound classified as Generally Recognized As Safe (GRAS) by the US Food and Drug Administration and the European Food Security Agency. Methods Ge-OH was orally administered at a maximum daily...

article

Simultaneous HS-SPME GC-MS determination of short chain fatty acids, trimethylamine and trimethylamine N-oxide for gut microbiota metabolic profile

Jessica Fiori, Silvia Turroni, Marco Candela, Patrizia Brigidi, more

Talanta > 2018 > 189 > C > 573-578

Trimethylamine (TMA), trimethylamine-N-oxide (TMAO) and short chain fatty acids (SCFAs), as acetic, propionic, butyric and valeric acids are among the most important products of the gut microbiota (GM) metabolism. The present study is aimed at the determination of TMA, TMAO and SCFAs by a double step headspace-solid phase microextraction (HS-SPME) and gas chromatography-mass spectrometry (GC-MS) analysis,...

article

Infant and Adult Gut Microbiome and Metabolome in Rural Bassa and Urban Settlers from Nigeria

Funmilola A. Ayeni, Elena Biagi, Simone Rampelli, Jessica Fiori, more

Cell Reports > 2018 > 23 > 10 > 3056-3067

We assessed the subsistence-related variation of the human gut microbiome at a fine resolution for two of the main dimensions of microbiome variation, age and geography. For this, we investigated the fecal microbiome and metabolome in rural Bassa and urbanized individuals from Nigeria, including infants, and compared data with worldwide populations practicing varying subsistence. Our data highlight...

article

Characterization of the human DNA gut virome across populations with different subsistence strategies and geographical origin

Simone Rampelli, Silvia Turroni, Stephanie L. Schnorr, Matteo Soverini, more

Environmental Microbiology > 19 > 11 > 4728 - 4735

It is a matter of fact that the human gut microbiome also includes a non‐bacterial fraction represented by eukaryotic cells and viruses. To further explore the gut microbiome variation in human populations, here we characterized the human DNA viral community from publicly available gut metagenome data sets from human populations with different geographical origin and lifestyle. In particular, such...

article

Gut microbiome response to short‐term dietary interventions in reactive hypoglycemia subjects

Sara Quercia, Silvia Turroni, Jessica Fiori, Matteo Soverini, more

Diabetes/Metabolism Research and Reviews > 33 > 8 > n/a - n/a

Background Reactive hypoglycemia is a metabolic disorder that provokes severe hypoglycemic episodes after meals. Over recent years, the gut microbiota has been recognized as potential target for the control of metabolic diseases, and the possibility to correct gut microbiota dysbioses through diet, favouring the recovery of metabolic homeostasis, has been considered. Methods We investigate the...

article

Occurrence of antibiotic resistance genes in the fecal DNA of healthy omnivores, ovo‐lacto vegetarians and vegans

Vesna Milanović, Andrea Osimani, Lucia Aquilanti, Stefano Tavoletti, more

Molecular Nutrition & Food Research > 61 > 9 > n/a - n/a

Scope The effects of long‐term omnivore, ovo‐lacto vegetarian and vegan diets on the occurrence of 12 antibiotic resistance (AR) genes in the human gut were studied. Methods and results The feces of 144 healthy volunteers recruited from Turin, Bari, Bologna, and Parma were screened for the occurrence of genes conferring resistance to tetracyclines, macrolide‐lincosamide‐streptogramin B, vancomycin,...

article

Immune-modulating effects in mouse dendritic cells of lactobacilli and bifidobacteria isolated from individuals following omnivorous, vegetarian and vegan diets

Diomira Luongo, Lucia Treppiccione, Alida Sorrentino, Ilario Ferrocino, more

Cytokine > 2017 > 97 > C > 141-148

Lactobacilli and bifidobacteria play a primary role in modulation of gut immunity. By considering that microbiota composition depends on various factors, including diet, we asked whether functional differences could characterize faecal populations of lactobacilli and bifidobacteria isolated from individuals with different dietary habits. 155 healthy volunteers who followed omnivorous, ovo-lacto-vegetarian...

article

The gut microbiota of centenarians: Signatures of longevity in the gut microbiota profile

Elena Biagi, Simone Rampelli, Silvia Turroni, Sara Quercia, more

Mechanisms of Ageing and Development > 2017 > 165 > PB > 180-184

The changing physiology and lifestyle of elderly people affect the gut microbiota composition, the changes of which can, in turn, affect the health maintenance of the ageing host. In a co-evolutionary vision of the relationship between gut microbiota and ageing as an adaptive process of the human superorganism, long-living individuals who get to “successfully” age might be the ones whose microbiota...

article

Temporal dynamics of the gut microbiota in people sharing a confined environment, a 520-day ground-based space simulation, MARS500

Silvia Turroni, Simone Rampelli, Elena Biagi, Clarissa Consolandi, more

Microbiome > 2017 > 5 > 1 > 1-11

Background The intestinal microbial communities and their temporal dynamics are gaining increasing interest due to the significant implications for human health. Recent studies have shown the dynamic behavior of the gut microbiota in free-living, healthy persons. To date, it is not known whether these dynamics are applicable during prolonged life sharing in a confined and controlled environment. ...

article

Modulation of the cytokine profile in Caco-2 cells by faecal lactobacilli and bifidobacteria from individuals with distinct dietary habits

Diomira Luongo, Annachiara Coppola, Lucia Treppiccione, Paolo Bergamo, more

Cytokine > 2017 > 90 > C > 80-87

Enterocytes are actively involved in the defense against pathogens and they limit penetration of commensal microbes into tissues. They also have an important role in gut immunity as enterocytes confer mucosal dendritic cell specialisation. On the other hand, the microbiota is directly involved in the development and modulation of the intestinal immune system. Particularly, lactobacilli and bifidobacteria...

article

Next-generation sequencing characterization of the gut bacterial community of gilthead sea bream (Sparus aurata, L.) fed low fishmeal based diets with increasing soybean meal levels

Luca Parma, Marco Candela, Matteo Soverini, Silvia Turroni, more

Animal Feed Science and Technology > 2016 > 222 > C > 204-216

The present study was carried out to evaluate growth, gut histology and gut bacterial community of gilthead sea bream (Sparus aurata) fed with increasing dietary soybean meal (SBM) levels in a low fishmeal (FM) based diet, in comparison with a control diet. Five isoproteic and isolipidic experimental diets were formulated to contain increasing levels of SBM (0, 100, 200, and 300gkg⁻¹ named S0, S10,...

article

Microbiota and lifestyle interactions through the lifespan

Simone Rampelli, Marco Candela, Silvia Turroni, Elena Biagi, more

Trends in Food Science & Technology > 2016 > 57 > PB > 265-272

The human intestinal microbiota is an adaptive entity, being capable of adjusting its phylogenetic and functional profile in response to changes in diet, lifestyle and environment. Providing the host with functions important to regulate energetic homeostasis and immunological function, the gut microbiota is strategic to keep metabolic and immunological homeostasis during the entire lifespan.In the...

article

Gut Microbiota and Extreme Longevity

Elena Biagi, Claudio Franceschi, Simone Rampelli, Marco Severgnini, more

Current Biology > 2016 > 26 > 11 > 1480-1485

The study of the extreme limits of human lifespan may allow a better understanding of how human beings can escape, delay, or survive the most frequent age-related causes of morbidity, a peculiarity shown by long-living individuals. Longevity is a complex trait in which genetics, environment, and stochasticity concur to determine the chance to reach 100 or more years of age [1]. Because of its impact...

article

ViromeScan: a new tool for metagenomic viral community profiling

Simone Rampelli, Matteo Soverini, Silvia Turroni, Sara Quercia, more

BMC Genomics > 2016 > 17 > 1 > 1-9

Background Bioinformatics tools available for metagenomic sequencing analysis are principally devoted to the identification of microorganisms populating an ecological niche, but they usually do not consider viruses. Only some software have been designed to profile the viral sequences, however they are not efficient in the characterization of viruses in the context of complex communities, like the...

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INFONA - science communication portal

Search results for: Silvia Turroni

Role of gut microbiome in the outcome of lymphoma patients treated with checkpoint inhibitors—The MicroLinf Study

Cerrado and Pantanal fruit flours affect gut microbiota composition in healthy and post‐COVID‐19 individuals: an in vitro pilot fermentation study

Gut microbiome–micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins?

The gut microbiome in pediatric patients undergoing allogeneic hematopoietic stem cell transplantation

HumanMycobiomeScan: a new bioinformatics tool for the characterization of the fungal fraction in metagenomic samples

Early gut microbiota signature of aGvHD in children given allogeneic hematopoietic cell transplantation for hematological disorders

Dietary geraniol ameliorates intestinal dysbiosis and relieves symptoms in irritable bowel syndrome patients: a pilot study

Simultaneous HS-SPME GC-MS determination of short chain fatty acids, trimethylamine and trimethylamine N-oxide for gut microbiota metabolic profile

Infant and Adult Gut Microbiome and Metabolome in Rural Bassa and Urban Settlers from Nigeria

Characterization of the human DNA gut virome across populations with different subsistence strategies and geographical origin

Gut microbiome response to short‐term dietary interventions in reactive hypoglycemia subjects

Occurrence of antibiotic resistance genes in the fecal DNA of healthy omnivores, ovo‐lacto vegetarians and vegans

Immune-modulating effects in mouse dendritic cells of lactobacilli and bifidobacteria isolated from individuals following omnivorous, vegetarian and vegan diets

The gut microbiota of centenarians: Signatures of longevity in the gut microbiota profile

Temporal dynamics of the gut microbiota in people sharing a confined environment, a 520-day ground-based space simulation, MARS500

Modulation of the cytokine profile in Caco-2 cells by faecal lactobacilli and bifidobacteria from individuals with distinct dietary habits

Next-generation sequencing characterization of the gut bacterial community of gilthead sea bream (Sparus aurata, L.) fed low fishmeal based diets with increasing soybean meal levels

Microbiota and lifestyle interactions through the lifespan

Gut Microbiota and Extreme Longevity

ViromeScan: a new tool for metagenomic viral community profiling

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