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Background Several methods have been developed to predict the pathogenicity of missense mutations but none has been specifically designed for classification of variants in mtDNA-encoded polypeptides. Moreover, there is not available curated dataset of neutral and damaging mtDNA missense variants to test the accuracy of predictors. Because mtDNA sequencing of patients suffering mitochondrial diseases...
Background Molecular evolution studies involve many different hard computational problems solved, in most cases, with heuristic algorithms that provide a nearly optimal solution. Hence, diverse software tools exist for the different stages involved in a molecular evolution workflow. Results We present MEvoLib, the first molecular evolution library for Python, providing a framework to work with different...
The wide availability of sequenced biological data has challenged the conventional methods and tools used in molecular biology to compute the conservation index. As the size of input datasets increases, the time-cost of current conservation methods is becoming unaffordable.
Most phylogeny estimation systems such as SATe2 or DACTAL use fixed configurations and tools that make them suitable only for solving specific problems. Out of that scope, a hand-made combination of individual tools and methods has to be composed in order to get the desired phylogeny estimation. PhyloFlow is a new framework based on a workflow extendable to a wide range of tasks in phylogenetic analysis...
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