Mahdi Eskandarian Boroujeni

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Functional dopaminergic neurons derived from human chorionic mesenchymal stem cells ameliorate striatal atrophy and improve behavioral deficits in Parkinsonian rat model

Vahid Ebrahimi, Mahdi Eskandarian Boroujeni, Abbas Aliaghaei, Mohammad Amin Abdollahifar, more

The Anatomical Record > 303 > 8 > 2274 - 2289

Human chorionic mesenchymal stem cells (HCMSCs) have been recognized as a desirable choice for cell therapy in neurological disorders such as Parkinson's disease (PD). Due to invaluable features of HCMSCs including their immunomodulatory and immunosuppressive properties, easily accessible and less differentiated compared to other types of MSCs, HCMSCs provide a great hope for regenerative medicine...

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Differential gene expression and stereological analyses of the cerebellum following methamphetamine exposure

Mahdi Eskandarian Boroujeni, Tahmineh Peirouvi, Fatemeh Shaerzadeh, Abolhasan Ahmadiani, more

Addiction Biology > 25 > 1 > n/a - n/a

Methamphetamine (METH) is a highly addictive psychostimulant that profoundly aimed at monoaminergic systems in the brain. Despite the leading role of cerebellum in sensorimotor control as well as augmented locomotor activity under the influence of METH, there are few studies examining the effect of METH administration on gene expression profiling and structural consequences in the cerebellar region...

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Complementation of dopaminergic signaling by Pitx3–GDNF synergy induces dopamine secretion by multipotent Ntera2 cells

Mahdi Eskandarian Boroujeni, Abbas Aliaghaei, Nader Maghsoudi, Mossa Gardaneh

Journal of Cellular Biochemistry > 121 > 1 > 200 - 212

Human teratocarcinoma cell line Ntera2 (NT2) expresses dopamine signals and has shown its safe profile for clinical applications. Attempts to restore complete dopaminergic (DAergic) phenotype enabling these cells to secrete dopamine have not been fully successful so far. We applied a blend of gene transfer techniques and a defined medium to convert NT2 cells to fully DAergic. The cells were primarily...

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Neuro-restorative effect of sertoli cell transplants in a rat model of amyloid beta toxicity

Abbas Aliaghaei, Arman Zeinaddini Meymand, Mahdi Eskandarian Boroujeni, Fariba Khodagoli, more

Behavioural Brain Research > 2019 > 367 > C > 158-165

Alzheimer’s disease (AD) is a degenerative nerve disease which adversely affects memory and learning skills. Currently, there is no disease-modifying therapeutic approach for AD. However, a growing body of literature suggests cell based therapies as a promising remedy for neurological disorders. Among the potential cell sources, testis- derived Sertoli cells (SCs) appear to be an attractive choice...

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A panel of noncoding RNAs in non–small‐cell lung cancer

Abouzar Bagheri, Hamid Reza Khorram Khorshid, Mahmood Tavallaie, Seyed Javad Mowla, more

Journal of Cellular Biochemistry > 120 > 5 > 8280 - 8290

Non–small‐lung cancer (NSCLC) is the leading cause of cancer death. Early detection of NSCLC could pave the way for effective therapies. Analysis of molecular genetic biomarkers in biological fluids has been proposed as a useful tool for cancer diagnosis. Here, we aimed to develop a panel of noncoding RNAs (ncRNAs) in sputum for NSCLC early detection. Expression of 11 ncRNAs were analyzed by real–time...

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Dental pulp stem cell transplantation ameliorates motor function and prevents cerebellar atrophy in rat model of cerebellar ataxia

Abbas Aliaghaei, Mahdi Eskandarian Boroujeni, Houssein Ahmadi, Amir-Hossein Bayat, more

Cell and Tissue Research > 2019 > 376 > 2 > 179-187

Cerebellar ataxias (CA) include a range of neurodegenerative disorders hallmarked by deterioration of the cerebellum. Cell replacement therapy (CRT) offers a potential remedy for the diseases associated with the central nervous system (CNS). This study was designed to assess the neurorestorative/protective effects of dental pulp stem cell (DPSC) implantation on a rat model of CA induced by 3-acetylpyridine...

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Dopaminergic induction of human adipose‐derived mesenchymal stem cells is accompanied by transcriptional activation of autophagy

Sanaz Hasani, Mahdi Eskandarian Boroujeni, Abbas Aliaghaei, Kaveh Baghai, more

Cell Biology International > 42 > 12 > 1688 - 1694

Neural differentiation involves drastic morphological alterations, essentially performed by a cell‐homeostasis maintaining process known as autophagy. Here, we used the cocktail of choroid plexus epithelial cell‐conditioned medium (CPEC‐CM) and 15% knockout serum (KS) to induce human adipose‐derived mesenchymal stem cells (hASCs) into tyrosine hydroxylase (TH)‐positive neuron like cells. We showed...

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Resveratrol Protects Purkinje Neurons and Restores Muscle Activity in Rat Model of Cerebellar Ataxia

Zeynab Ghorbani, Reza Mastery Farahani, Abbas Aliaghaei, Fariba Khodagholi, more

Journal of Molecular Neuroscience > 2018 > 65 > 1 > 35-42

Cerebellar ataxia (CA) is regarded as a miscellaneous cluster of brain disorders related to the cerebellum. Resveratrol is a naturally occurring polyphenolic compound. Previous reports suggest that resveratrol confers neuroprotection in various animal models of brain damage. Indeed, we considered it invaluable to investigate whether a treatment with resveratrol has a therapeutic role against CA induced...

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Sertoli Cells Avert Neuroinflammation-Induced Cell Death and Improve Motor Function and Striatal Atrophy in Rat Model of Huntington Disease

Houssein Ahmadi, Mahdi Eskandarian Boroujeni, Yousef Sadeghi, Mohammad Amin Abdollahifar, more

Journal of Molecular Neuroscience > 2018 > 65 > 1 > 17-27

Huntington’s disease (HD) is a genetically heritable disorder, linked with continuing cell loss and degeneration mostly in the striatum. Currently, cell therapy approaches in HD have essentially been focused on replenishing or shielding cells lost over the period of the disease. Herein, we sought to explore the in vitro and in vivo efficacy of primary rat Sertoli cells (SCs) and their paracrine effect...

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Human Umbilical Cord Matrix Stem Cells Reverse Oxidative Stress-Induced Cell Death and Ameliorate Motor Function and Striatal Atrophy in Rat Model of Huntington Disease

Mohammad Javad Ebrahimi, Abbas Aliaghaei, Mahdi Eskandarian Boroujeni, Fariba Khodagholi, more

Neurotoxicity Research > 2018 > 34 > 2 > 273-284

Huntington disease (HD) is an inherited disorder hallmarked by progressive deterioration of specific neurons, followed by movement and cognitive anomalies. Cell therapy approaches in neurodegenerative conditions have concentrated on the replenishment of lost/dying neurons with functional ones. Multipotent mesenchymal stem cells (MSCs) have been represented as a potential remedy for HD. In this study,...

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The Superiority of Sucrose Cushion Centrifugation to Ultrafiltration and PEGylation in Generating High-Titer Lentivirus Particles and Transducing Stem Cells with Enhanced Efficiency

Mahdi Eskandarian Boroujeni, Mossa Gardaneh

Molecular Biotechnology > 2018 > 60 > 3 > 185-193

Viral gene delivery is hailed as a great milestone in gene-based therapeutic approaches. The human immunodeficiency virus-derived lentiviral vectors (LVs) are advantageous in infecting both dividing and non-dividing cells leading to continuous expression of transgenes. A variety of protocols are available for concentration of LVs. We primarily generated our internal ribosome entry site (IRES)-based...

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Search results for: Mahdi Eskandarian Boroujeni

Functional dopaminergic neurons derived from human chorionic mesenchymal stem cells ameliorate striatal atrophy and improve behavioral deficits in Parkinsonian rat model

Differential gene expression and stereological analyses of the cerebellum following methamphetamine exposure

Complementation of dopaminergic signaling by Pitx3–GDNF synergy induces dopamine secretion by multipotent Ntera2 cells

Neuro-restorative effect of sertoli cell transplants in a rat model of amyloid beta toxicity

A panel of noncoding RNAs in non–small‐cell lung cancer

Dental pulp stem cell transplantation ameliorates motor function and prevents cerebellar atrophy in rat model of cerebellar ataxia

Dopaminergic induction of human adipose‐derived mesenchymal stem cells is accompanied by transcriptional activation of autophagy

Resveratrol Protects Purkinje Neurons and Restores Muscle Activity in Rat Model of Cerebellar Ataxia

Sertoli Cells Avert Neuroinflammation-Induced Cell Death and Improve Motor Function and Striatal Atrophy in Rat Model of Huntington Disease

Human Umbilical Cord Matrix Stem Cells Reverse Oxidative Stress-Induced Cell Death and Ameliorate Motor Function and Striatal Atrophy in Rat Model of Huntington Disease

The Superiority of Sucrose Cushion Centrifugation to Ultrafiltration and PEGylation in Generating High-Titer Lentivirus Particles and Transducing Stem Cells with Enhanced Efficiency

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