Search results for: Takashi Izawa

Items from 1 to 14 out of 14 results

article

Novel prediction models for pharyngeal‐airway volume based on the cranial‐base and midsagittal cross‐sectional area of the airway in the pharyngeal region: A cephalometric and magnetic resonance imaging study

Janvier Habumugisha, Masahiro Nakamura, Kana Kono, Kenta Uchida, more

Orthodontics & Craniofacial Research > 27 > 3 > 394 - 402

Objective The objective of the study was to elucidate the association between cranial base (Bjork‐Jarabak analysis), midsagittal cross‐sectional area of the airway in the pharyngeal region (MCSA‐PR) data and pharyngeal‐airway volume (PAV) and develop a model that could help clinicians predict PAV using two‐dimensional (2D) data (Bjork polygon and MCSA‐PR). Materials and Methods Pre‐treatment lateral...

article

HIF‐1α controls palatal wound healing by regulating macrophage motility via S1P/S1P₁ signaling axis

Islamy Rahma Hutami, Takashi Izawa, Tsendsuren Khurel‐Ochir, Takuma Sakamaki, more

Oral Diseases > 28 > 4 > 1157 - 1169

Objectives To investigate the role of hypoxia‐inducible factor 1α (HIF‐1α) signaling, the expression profile of M1 and M2 macrophages, and the role of the sphingosine 1‐phosphate (S1P)/S1P receptor system in palatal wound healing of heterozygous HIF‐1α‐deficient (HIF‐1α HET) mice. Materials and methods HIF‐1α HET and wild‐type (WT) littermates underwent palatal tissue excision at the mid‐hard palate...

article

O‐GlcNAcylation drives calcium signaling toward osteoblast differentiation: A bioinformatics‐oriented study

Yao Weng, Ziyi Wang, Yoko Fukuhara, Airi Tanai, more

BioFactors > 47 > 6 > 992 - 1015

This study aimed to reveal the possible mechanisms by which O‐linked‐N‐acetylglucosaminylation (O‐GlcNAcylation) regulates osteoblast differentiation using a series of bioinformatics‐oriented experiments. To examine the influence of O‐GlcNAcylation levels on osteoblast differentiation, osteoblastic MC3T3‐E1 cells were treated with O‐GlcNAc transferase (OGT) and O‐GlcNAcase (OGA) inhibitors. Correlations...

article

Skeletal open bite with amelogenesis imperfecta treated with compression osteogenesis: a case report

Hiroki Mori, Takashi Izawa, Hitoshi Mori, Keiichiro Watanabe, more

Head & Face Medicine > 2019 > 15 > 1 > 1-7

Background We successfully treated a 37-year-old male who had skeletal open bite with severe amelogenesis imperfecta (AI) with orthodontics, compression osteogenesis, and prosthodontics. Case presentation The patient was diagnosed with severe anterior open bite caused by severe AI. Corticotomy was performed on both buccal and palatal sides of the molar regions, and anchor plates were placed onto...

article

Fas/S1P1 crosstalk via NF-κB activation in osteoclasts controls subchondral bone remodeling in murine TMJ arthritis

Islamy Rahma Hutami, Takashi Izawa, Akiko Mino-Oka, Takehiro Shinohara, more

Biochemical and Biophysical Research Communications > 2017 > 490 > 4 > 1274-1281

Enhanced turnover of subchondral trabecular bone is a hallmark of rheumatoid arthritis (RA) and it results from an imbalance between bone resorption and bone formation activities. To investigate the formation and activation of osteoclasts which mediate bone resorption, a Fas-deficient MRL/lpr mouse model which spontaneously develops autoimmune arthritis and exhibits decreased bone mass was studied...

chapter

Nonlinearity compensation of micro-mirror hard-spring by electrostatic combs

Takashi Izawa, Takashi Sasaki, Kazuhiro Hane

2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS) > 1987 - 1990

2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS)

Torsion bar of micro-mirror scanner often shows hard-spring effect, which bends the oscillation curve and causes instability such as hysteresis. In this report, we propose a method to compensate equivalently the hard-spring nonlinearity of micro-mirror scanner using the electrostatic combs. A 0.02% bend of the oscillation curve of the micro-mirror scanner was compensated by an applied comb voltage...

article

Long-term follow-up of a patient with achondroplasia treated with an orthodontic approach

Hiroyo Mori, Kazuma Matsumoto, Nobuhiko Kawai, Takashi Izawa, more

American Journal of Orthodontics and Dentofacial Orthopedics > 2017 > 151 > 4 > 793-803

We successfully treated a patient with achondroplasia with conventional orthodontic techniques. It was followed by long-term retention. The patient, a 12-year-old boy, had chief complaints of occlusal disturbance and mandibular protrusion. He had been diagnosed with achondroplasia and had growth hormone treatment in his early teenage years. His facial profile was concave with a bulging forehead and...

chapter

4.9 A 1ms high-speed vision chip with 3D-stacked 140GOPS column-parallel PEs for spatio-temporal image processing

Tomohiro Yamazaki, Hironobu Katayama, Shuji Uehara, Atsushi Nose, more

2017 IEEE International Solid-State Circuits Conference (ISSCC) > 82 - 83

2017 IEEE International Solid- State Circuits Conference - (ISSCC)

High-speed vision systems that combine high-frame-rate imaging and highly parallel signal processing enable instantaneous visual feedback to rapidly control machines over human-visual-recognition speeds. Such systems also enable a reduction in circuit scale by using a fast and simple algorithm optimized for high-frame-rate processing [1]. Previous studies on vision systems and chips [1–4] have yielded...

article

Roles of hypoxia inducible factor-1α in the temporomandibular joint

Akiko Mino-Oka, Takashi Izawa, Takehiro Shinohara, Hiroki Mori, more

Archives of Oral Biology > 2017 > 73 > C > 274-281

Temporomandibular joint osteoarthritis (TMJ-OA) is a degenerative disease characterized by permanent cartilage loss. Articular cartilage is maintained in a low-oxygen environment. The chondrocyte response to hypoxic conditions involves expression of hypoxia inducible factor 1α (HIF-1α), which induces chondrocytes to increase expression of vascular endothelial growth factor (VEGF). Here, we investigated...

article

Amelotin gene expression is temporarily being upregulated at the initiation of apoptosis induced by TGFβ1 in mouse gingival epithelial cells

Yohei Nakayama, Sari Matsui, Keisuke Noda, Mizuho Yamazaki, more

Apoptosis > 2016 > 21 > 10 > 1057-1070

Amelotin (AMTN) is expressed and secreted by ameloblasts in the maturation stage of amelogenesis and persist with low levels in the junctional epithelium (JE) of erupted teeth. The purpose of this study is to investigate the transcriptional regulation of the AMTN gene by transforming growth factor beta1 (TGFβ1) in gingival epithelial (GE1) cells in the apoptosis phase. Apoptosis was evaluated by the...

article

The Effectiveness of Human Parathyroid Hormone and Low-Intensity Pulsed Ultrasound on the Fracture Healing in Osteoporotic Bones

Karima Q. Mansjur, Shingo Kuroda, Takashi Izawa, Yuichi Maeda, more

Annals of Biomedical Engineering > 2016 > 44 > 8 > 2480-2488

Osteoporotic fracture has become a major public health problem, and until today, the treatments available are not satisfactory. While there is growing evidence to support the individual treatment of parathyroid hormone (PTH) administration and low-intensity pulsed ultrasound (LIPUS) exposure as respectively systemic and local therapies during osteoporotic fracture healing, their effects have not yet...

article

Smad3 Deficiency Leads to Mandibular Condyle Degradation via the Sphingosine 1-Phosphate (S1P)/S1P3 Signaling Axis

Hiroki Mori, Takashi Izawa, Eiji Tanaka

The American Journal of Pathology > 2015 > 185 > 10 > 2742-2756

Temporomandibular joint osteoarthritis is a degenerative disease that is characterized by permanent cartilage destruction. Transforming growth factor (TGF)-β is one of the most abundant cytokines in the bone matrix and is shown to regulate the migration of osteoprogenitor cells. It is hypothesized that TGF-β/Smad3 signaling affects cartilage homeostasis by influencing sphingosine 1-phosphate (S1P)/S1P...

article

ASXL2 Regulates Glucose, Lipid, and Skeletal Homeostasis

Takashi Izawa, Nidhi Rohatgi, Tomohiro Fukunaga, Qun-Tian Wang, more

Cell Reports > 2015 > 11 > 10 > 1625-1637

ASXL2 is an ETP family protein that interacts with PPARγ. We find that ASXL2−/− mice are insulin resistant, lipodystrophic, and fail to respond to a high-fat diet. Consistent with genetic variation at the ASXL2 locus and human bone mineral density, ASXL2−/− mice are also severely osteopetrotic because of failed osteoclast differentiation attended by normal bone formation. ASXL2 regulates the osteoclast...

article

Analysis of gene expression profiles in human periodontal ligament cells under hypoxia: The protective effect of CC chemokine ligand 2 to oxygen shortage

Yukiko Kitase, Masahiko Yokozeki, Shinji Fujihara, Takashi Izawa, more

Archives of Oral Biology > 2009 > 54 > 7 > 618-624

Periodontal ligament (PDL) cells appear to play important functional roles in response to mechanical stress. We hypothesized that hypoxia caused by a deformation of blood vessels and the following ischaemia may play a crucial role in differential gene expression in PDL cells affected by mechanical stress. Gene induction in cultured human PDL cells by hypoxia was analyzed using cDNA array, followed...

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