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Aims/hypothesis Type 2 diabetes is more prevalent in African-Americans (AFAs) and Hispanic-Americans (HAs) than in European-Americans. We assessed whether continental admixture was correlated with diabetes risk in these high-risk groups. Methods We estimated the proportion of sub-Saharan African (AFR), Amerindian (AMI) and European admixture using 92 ancestry-informative marker genotypes in 16,476...
To examine the genetics of susceptibility to primary biliary cirrhosis (PBC), genome‐wide association studies GWAS have been performed in patients of European ancestry and have shown the significant associations of IL12‐related pathways, SPIB, IRF5‐TNPO3, and 17q12‐21. We tested whether these findings could be extended to a Japanese cohort, 303 Japanese PBC and 298 controls. We failed to detect significant...
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