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An extreme genetic risk for type 1 diabetes (T1D) was reported for DR3/4‐DQ8 siblings sharing both extended human leukocyte antigen (HLA) haplotypes identical‐by‐descent (IBD) with their diabetic proband. We attempted to replicate this finding in our prospective Dutch T1D cohort and in families from the Type 1 Diabetes Genetics Consortium (T1DGC). Only 2 of the 14 Dutch siblings, sharing both DR3‐DQ2/DR4‐DQ8...
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