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Obese subjects need additional energy to move larger bodies and a greater amount of O2 to accomplish an equal external work-load than lean subjects. Moreover, obesity is characterized by a marked insulin resistance, which may modify metabolic responses to physical exercise. We measured the respiratory and metabolic responses to a progressive ergometric test in a group of 10 men obese and in 10 lean...
Muscle biopsy in a neonate with features of Yunis Varon syndrome revealed a vacuolar myopathy with evidence of lysosomal storage disease. Similar vacuoles were also present in heart, cartilage, central nervous system and cultured fibroblasts. Although the histologic findings in the central nervous system resembled those of infantile acid maltase deficiency, the essayed lysosomal enzymes were normal...
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