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Mouse models of cardiac diseases have proven to be a valuable tool in preclinical research. The rapid heart and respiratory rates of free breathing mice and the consequent technical challenges up to now prohibit in vivo perfusion studies, e.g. of the myocardium, even if gating methods are applied. This makes a sacrification of the animals unavoidable and only allows for the application of static ex...
Our aim was to prospectively compare two post-processing techniques for dynamic contrast-enhanced ultrasound and to evaluate their impact for monitoring antiangiogenic therapy.Thus, mice with epidermoid carcinoma xenografts were examined during administration of polybutylcyanoacrylate-microbubbles using a small animal ultrasound system (40MHz). Cine loops were acquired and analyzed using time–intensity...
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