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Colon cancer initiating cells (CCICs) are more tumorigenic and metastatic than the majority of colorectal cancer (CRC) cells. CCICs have also been associated with stem cell-like properties. However, there is a lack of system-level understanding of what mechanisms distinguish CCICs from common CRC cells. We compared the transcriptomes of CD133+ CCICs and CD133- CRC cells from multiple sources, which...
Extensive understanding and management of the thermal-mechanical characteristics of novel packaging designs during the bonding process are indispensable to the realization of the technologies. Thus, this paper attempts to explore the bonding process-induced thermal-mechanical behaviors of an advanced flip chip (FC) electronic packaging. FC packaging employs a novel anisotropic conductive film, which...
The process-induced thermal-mechanical behaviors of the np ACF typed FC technology during bonding process and temperature variation are investigated. For achieving the goal, a process-dependent simulation methodology is introduced, which incorporates a transient thermal and static thermal-mechanical finite element (FE) modeling and a "death-birth" meshing scheme. Prior to the modeling, the...
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