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Compound screening is a powerful tool to identify new therapeutic targets, drug leads, and elucidate the fundamental mechanisms of biological processes. We report here the results of the first in vivo small-molecule screens for compounds enhancing neuronal regeneration. These screens are enabled by the microfluidic devices we have developed for C. elegans. The devices enable rapid and repeatable animal...
Techniques for rapid and automated small-animal manipulation and immobilization are necessary for high-throughput in vivo genetic/drug screens using cellular and sub-cellular features in multicellular organisms. We present a suite of technologies for complex high-throughput whole-animal genetic and drug screens. We demonstrate a high-speed microfluidic sorter that can isolate and immobilize Caenorhabditis...
We present a suite of technologies that can be combined to perform complex high-throughput whole-animal genetic and drug screens. When used in various combinations, these devices facilitate a variety of high-throughput assays using whole animals.
We developed microfluidic devices, imaging algorithms and femtosecond laser microsurgery technologies to manipulate large numbers of small-animals on a single chip for sub-cellular resolution high-throughput genetic and drug screens on neural degeneration and regeneration.
We developed microfluidic devices, imaging algorithms and femtosecond laser microsurgery technologies to manipulate large numbers of small-animals on a single chip for sub-cellular resolution high-throughput genetic and drug screens on neural degeneration and regeneration.
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