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Modified Rayleigh-Plesset models are commonly used to characterize the acoustic response of microbubbles under ultrasound exposure. In most instances these models have been parameterized through acoustic measurements taken from bulk suspensions of microbubbles. The aim of this study was to parameterize the Hoff model for the commercial contrast agent SonoVue using optically observed oscillations from...
In this investigation, a high speed camera was used to measure the radial oscillations of the commercial contrast agent SonoVuetrade and in-house microbubble preparations of differing lipid compositions at low insonation pressures. It was found that a significant proportion (~75%) of the microbubbles shrank during insonation, possibly due to gas diffusion and/or excess lipid shedding. Microbubble...
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