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This paper reports on the fabrication of hollow microneedle electrodes with fluidic channels arranged in 8times8 arrays. Features of these electrodes include (i) an increased surface area for improved intracellular potential measurements with simultaneous membrane cell poration capabilities, (ii) their potential use in highly parallel patch-clamp applications and (iii) the ability to efficiently inject...
This paper reports on the fabrication and application of microneedles for the electroporation of adherently growing cells and intracellular recording with focus on the influence on external factors on the cell behavior. Patch-on-chip methods such as patch-clamp have been applied mostly to individual cells in suspension. However, in the human body most of cells are adherently growing cells, which motivated...
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