Search results for: Francesca Barone

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Maladaptive Autophagy in the Pathogenesis of Autoimmune Epithelitis in Sjögren's Syndrome

Serena Colafrancesco, Cristiana Barbati, Roberta Priori, Erisa Putro, more

Arthritis & Rheumatology > 74 > 4 > 654 - 664

Objective Salivary gland epithelial cells (SGECs) are key cellular drivers in the pathogenesis of primary Sjögren's syndrome (SS); however, the mechanisms sustaining SGEC activation in primary SS remain unclear. We undertook this study to determine the role of autophagy in the survival and activation of SGECs in primary SS. Methods Primary SGECs isolated from the minor SGs of patients with primary...

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Stromal cells in tertiary lymphoid structures: Architects of autoimmunity

Saba Asam, Saba Nayar, David Gardner, Francesca Barone

Immunological Reviews > 302 > 1 > 184 - 195

The molecular mediators present within the inflammatory microenvironment are able, in certain conditions, to favor the initiation of tertiary lymphoid structure (TLS) development. TLS is organized lymphocyte clusters able to support antigen‐specific immune response in non‐immune organs. Importantly, chronic inflammation does not always result in TLS formation; instead, TLS has been observed to develop...

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Improvement of Severe Fatigue Following Nuclease Therapy in Patients With Primary Sjögren’s Syndrome: A Randomized Clinical Trial

James Posada, Saba Valadkhan, Daniel Burge, Kristen Davies, more

Arthritis & Rheumatology > 73 > 1 > 143 - 150

Objective To assess the safety and efficacy of RSLV‐132, an RNase Fc fusion protein, in a phase II randomized, double‐blind, placebo‐controlled clinical trial in patients with primary Sjögren’s syndrome (SS). Methods Thirty patients with primary SS were randomized to receive treatment with RSLV‐132 or placebo intravenously once per week for 2 weeks, and then every 2 weeks for 12 weeks. Eight patients...

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Autonomic effects induced by pharmacological activation and inhibition of Raphe Pallidus neurons in anaesthetized adult pigs

Mino Zucchelli, Stefano Bastianini, Domenico Ventrella, Francesca Barone, more

Clinical and Experimental Pharmacology and Physiology > 47 > 2 > 281 - 285

The Raphe Pallidus (RPa) is a region of the brainstem that was shown to modulate the sympathetic outflow to many tissues and organs involved in thermoregulation and energy expenditure. In rodents, the pharmacological activation of RPa neurons was shown to increase the activity of the brown adipose tissue, heart rate, and expired CO₂, whereas their inhibition was shown to induce cutaneous vasodilation...

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Ultrasound guided spinal catheter insertion in piglet: preliminary results

Noemi Romagnoli, Carlotta Lambertini, Domenico Ventrella, Dario Floriano, more

Veterinary Anaesthesia and Analgesia > 2017 > 44 > 6 > 1391-1396

To describe the ultrasound (US) evaluation of the cervical, thoracic and lumbar spinal tracts in piglets and to evaluate the feasibility of the ultrasound guided spinal catheter placement in newborn and paediatric piglets.Prospective experimental study.A total of two piglet cadavers (age, 7 and 14 days) and eight commercial crossbreed piglets divided into four groups according to age: 7 (P7), 14 (P14),...

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The biomedical piglet: establishing reference intervals for haematology and clinical chemistry parameters of two age groups with and without iron supplementation

Domenico Ventrella, Francesco Dondi, Francesca Barone, Federica Serafini, more

BMC Veterinary Research > 2016 > 13 > 1 > 1-8

Background The similarities between swine and humans in physiological and genomic patterns, and the great correlation in size and anatomy, make pigs extremely useful in preclinical studies. New-born piglets can represent a model for congenital and genetic diseases in new-born children. It is known that piglets may have significant differences in clinicopathological results compared to adult pigs....

article

Periodontitis prevalence and serum antibody reactivity to periodontal bacteria in primary Sjögren's syndrome: a pilot study

Bozo Lugonja, Lorraine Yeo, Michael R. Milward, Diana Smith, more

Journal of Clinical Periodontology > 43 > 1 > 26 - 33

AimsThe aims of this study were as follows: (i) To assess the prevalence of periodontitis among patients with primary Sjögren's syndrome (pSS) and comparator groups of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). (ii) To perform a pilot study to compare serum antibody responses to 10 oral/periodontal bacteria in these patient groups and a historical comparator group of patients...

article

Preface

Francesca Barone, Rik Lories

Best Practice & Research Clinical Rheumatology > 2015 > 29 > 6 > 681-682

article

Transdermal spinal catheter placement in piglets: Description and validation of the technique

Carlotta Lambertini, Domenico Ventrella, Francesca Barone, Nicolina Cristina Sorrentino, more

Journal of Neuroscience Methods > 2015 > 255 > Complete > 17-21

The swine species represents a perfect model for translational medicine due to its physiological and anatomical resemblance to humans. The development of techniques for spinal catheter insertion in swine is significantly useful but, at the moment, the only technique described requires laminectomy as a surgical approach.The proposed techniques represent a transdermal approach for catheter placement...

article

The expression of mouse CLEC‐2 on leucocyte subsets varies according to their anatomical location and inflammatory state

Kate L. Lowe, Leyre Navarro‐Núñez, Cécile Bénézech, Saba Nayar, more

European Journal of Immunology > 45 > 9 > 2484 - 2493

Expression of mouse C‐type lectin‐like receptor 2 (CLEC‐2) has been reported on circulating CD11b^high Gr‐1^high myeloid cells and dendritic cells (DCs) under basal conditions, as well as on a variety of leucocyte subsets following inflammatory stimuli or in vitro cell culture. However, previous studies assessing CLEC‐2 expression failed to use CLEC‐2‐deficient mice as negative controls and instead...

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Stroma: Fertile soil for inflammation

Rikesh Patel, Andrew Filer, Francesca Barone, Christopher D. Buckley

Best Practice & Research Clinical Rheumatology > 2014 > 28 > 4 > 565-576

Biological therapies for the management of immune mediated inflammatory diseases such as rheumatoid arthritis have proven to be extremely successful in recent years. Despite these successes, even the most effective of therapies do not lead to cure. Why chronic inflammation persists indefinitely within the rheumatoid synovium despite an absence of continuous stimulation, and why some patients with...

article

Fruit Regulates Bud Sprouting and Vegetative Growth in Field-Grown Loquat Trees (Eriobotrya japonica Lindl.): Nutritional and Hormonal Changes

Carmina Reig, Vittorio Farina, Carlos Mesejo, Amparo Martínez-Fuentes, more

Journal of Plant Growth Regulation > 2014 > 33 > 2 > 222-232

The effects of fruit on bud sprouting and vegetative growth were compared on fruiting and defruited loquat trees from fruit set onward. Carbohydrate and nitrogen content in leaves and bark tissues and hormone concentrations were studied during the fruit development and vegetative growth periods. On defruited trees, a significant proportion of buds sprouted in winter, whereas buds from fruiting trees...

article

Gibberellic acid and flower bud development in loquat (Eriobotrya japonica Lindl.)

Carmina Reig, Vittorio Farina, Giorgio Volpe, Carlos Mesejo, more

Scientia Horticulturae > 2011 > 129 > 1 > 27-31

The application of gibberellic acid (GA ₃ ) to the whole loquat tree from mid-May to early June and from early August to the onset of flowering, significantly reduced the number of premature flowering shoots per current shoot and per m ³ of canopy, and so reduced the total number of panicles per m ³ of canopy. The number of vegetative shoots per m ³ of canopy was also...

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IgA-Producing Plasma Cells Originate From Germinal Centers That Are Induced by B-Cell Receptor Engagement in Humans

Francesca Barone, Anna Vossenkamper, Laurent Boursier, Wen Su, more

Gastroenterology > 2011 > 140 > 3 > 947-956

IgA contributes to homeostatic balance between host and intestinal microbiota. Mechanisms that initiate the IgA response are unclear and likely to differ between humans and animal models. We used multiple experimental approaches to investigate the origin of human intestinal plasma cells that produce IgA in the gastrointestinal tract.Complexity of IgA-producing plasma cell populations in human gastrointestinal...

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Antisense transcripts of V(D)J rearrangements; artifacts caused by false priming?

Yuan Zhao, Deborah K. Dunn-Walters, Francesca Barone, Jo Spencer

Molecular Immunology > 2009 > 46 > 11-12 > 2357-2362

Somatic hypermutation (SH) of V(D)J rearrangements at the IGH and IGL loci diversifies the IG repertoire during the germinal center response. SH is absolutely dependent on the enzyme activation induced cytidine deaminase (AID) that initiates the SH process by deaminating C nucleotides in ssDNA. Mutations from G and C are thought to occur as a result of strand symmetrical deamination of C by AID on...

article

Generation of Immunoglobulin diversity in human gut-associated lymphoid tissue

Jo Spencer, Francesca Barone, Deborah Dunn-Walters

Seminars in Immunology > 2009 > 21 > 3 > 139-146

The organised gut associated lymphoid tissue (GALT) exists adjacent to an extensive and diverse luminal flora. The follicle associated epithelium and associated dendritic cells and lymphocytes form a tightly fortified gateway between the flora and the host that permits connectivity between them and chronic activation of the lymphoid compartment. As a consequence, plasma cell precursors are generated...

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