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Background
Genome‐wide association studies (GWASs) of asthma have identified several risk alleles and loci, but most have been conducted in individuals with European‐ancestry. Studies in Asians, especially children, are still lacking. We aimed to identify susceptibility loci by performing the first GWAS of asthma in Korean children with persistent asthma.
Methods
We used a discovery set of 741...
We have developed a microarray to study the expression of L-chain V genes (V L genes) in healthy and SLE patient peripheral κ- and λ-sorted B cells. In all repertoires tested, one V L gene accounts for over 10% of all gene V L expression, consistent with positive selection acting on L-chains. While a few V L genes were highly expressed in all individuals, most V ...
Spleen tyrosine kinase (Syk), a key mediator of immunoreceptor signaling in inflammatory cells, is essential for immune complex-mediated signal transduction initiated by activated receptors for immunoglobulin G. In collagen-induced arthritis, R788/R406, a novel and potent small molecule Syk inhibitor suppressed clinical arthritis, bone erosions, pannus formation, and synovitis. Serum anti-collagen...
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