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Immunoglobulins loci in mammals are well known to be organized within a translocon, however their origin remains unresolved. Four of the five classes of immunoglobulins described in humans and rodents (immunoglobulins M, G, E and A—IgM, IgG, IgE and IgA) were found in marsupials and monotremes (immunoglobulin D—IgD was not found) thus showing that the genomic structure of antibodies in mammals has...
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