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In designing scientific experiments, power analysis is too often given a superficial treatment— choice of sample size is often made based on idealized distributions and simplistic tests that do not reflect the real-world constraints under which the actual data will be collected. We have developed a general Monte Carlo framework for two-group comparisons which samples points from a two-dimensional...
We have developed a data summarization tool called Chi2notype which leverages the star schema of the Integrating Informatics from Bench to Bedside (i2b2) vendor-neutral data-warehouse platform to characterize a patient-cohort of interest. Chi2notype calculates a chi-squared statistic for every one of the hundreds of thousands of variables in an Electronic Medical Record (EMR) system and uses it to...
There are many legitimate reasons why standards for formatting of biomedical research data are lengthy and complex (Souza, Kush, & Evans, 2007). However, the common scenario of a biostatistician simply needing to import a given dataset into their statistical software is at best under-served by these standards. Statisticians are forced to act as amateur database administrators to pivot and join...
Introduction: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease. We sought to determine whether peroxisome proliferator–activated receptor γ coactivator 1α (PGC‐1α) would have a beneficial effect on this disease. Methods: PGC‐1α transgenic mice were crossed with SOD1 mutant G93A DL mice. Results: We observed a moderate but non‐significant increase in average lifespan in...
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