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Systems approaches have been used to describe molecular signatures driving immunity to influenza vaccination in humans. Whether such signatures are similar across multiple seasons and in diverse populations is unknown. We applied systems approaches to study immune responses in young, elderly, and diabetic subjects vaccinated with the seasonal influenza vaccine across five consecutive seasons. Signatures...
Current UK national standards recommend routine bacteriology surveillance in severe antibody‐deficient patients, but less guidance exists on virology screening and viral infections in these patients. In this retrospective audit, we assessed the proportion of positive virology or bacteriology respiratory and stool samples from patients with severe, partial or no immune deficiency during a 2‐year period...
Dendritic cell (DC) subsets can mediate diverse responses, but little is known about the Toll‐like receptor (TLR) signalling pathways in different human DC subsets. Despite expressing many TLRs in common, we found that in vitro‐derived Langerhans cells (LCs) and monocyte‐derived DCs (moDCs) undergo differential signalling events following TLR stimulation. TLR‐stimulated LCs did not secrete interleukin...
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