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Systems approaches have been used to describe molecular signatures driving immunity to influenza vaccination in humans. Whether such signatures are similar across multiple seasons and in diverse populations is unknown. We applied systems approaches to study immune responses in young, elderly, and diabetic subjects vaccinated with the seasonal influenza vaccine across five consecutive seasons. Signatures...
Dendritic cell (DC) subsets can mediate diverse responses, but little is known about the Toll‐like receptor (TLR) signalling pathways in different human DC subsets. Despite expressing many TLRs in common, we found that in vitro‐derived Langerhans cells (LCs) and monocyte‐derived DCs (moDCs) undergo differential signalling events following TLR stimulation. TLR‐stimulated LCs did not secrete interleukin...
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